Search Results
Overview
| Uniprot ID | D3Z914 |
|---|---|
| Protein Name | SOSS complex subunit C |
| Gene Name | Inip |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | LSRPSLSKDFRDHAE |
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs)
Protein Sequence
10
MAANPSGQGF
20
QNKNRVAILA
30
ELDKEKRKLL
40
MQNQSSASHP
50
GASISLSRPS
60
LSKDFRDHAE
70
QQHIAAQQKA
80
ALQHAHAHSS
90
GYFITQDSAF
100
GNLILPVLPR
LDPE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035861 | site of double-strand break |
| Cellular Component | GO:0070876 | SOSS complex |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:0044818 | mitotic G2/M transition checkpoint |
| Biological Process | GO:0010212 | response to ionizing radiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.