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Overview

Uniprot IDD3Z941
Protein NameMethionine--tRNA ligase, cytoplasmic
Gene NameMars1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
868 LKAQKADKNQVAAEV

Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus

Protein Sequence

10 MRLFVSEGSP 20 GSLPVLAAAA 30 RARGRAELLI 40 STVGPEECVV 50 PFLTRPKVPV 60 LQLDSGNYLF 70 SASAICRYFF 80 LLCGWEQDDL 90 TNQWLEWEAT 100 ELQPVLSAAL 110 YCLVVQGKKG 120 EDVLGPLRRV 130 LTHIDHSLSR 140 QNCPFLAGDT 150 ESLADIVLWG 160 ALYPLLQDPA 170 YLPEELGALQ 180 SWFQTLSTQE 190 PCQRAAETVL 200 KQQGVLALRP 210 YLQKQPQPQP 220 LPPEGRAVSN 230 EPEEEELATL 240 SEEDIIAAVA 250 AWEKGLENLP 260 PLQPQQHPVL 270 PVPGERNVLI 280 TSALPYVNNV 290 PHLGNIIGCV 300 LSADVFARYS 310 RLRQWNTLYL 320 CGTDEYGTAT 330 ETKAMEEGLT 340 PQEICDKYHA 350 IHVDIYRWFN 360 ISFDTFGRTT 370 TPLQTKITQD 380 IFQRLLTRGF 390 VLQDTVEQLR 400 CEQCARFLAD 410 RFVEGVCPFC 420 GYEEARGDQC 430 DKCGKLINAI 440 ELKRPQCKVC 450 RSHPVVKSSK 460 HLFLDLPKLE 470 KRLEDWLGKT 480 MPGSDWTPNA 490 RFIIRSWLRD 500 GLKPRCITRD 510 LKWGTPVPLE 520 GFEDKVFYVW 530 FDATIGYLSI 540 TANYTDQWER 550 WWKNPEQVDL 560 YQFMAKDNVP 570 FHGLVFPCSA 580 LGAEDNYTLV 590 KNLIATEYLN 600 YEDGKFSKSR 610 GIGVFGDMAQ 620 DTGIPADIWR 630 FYLLYIRPEG 640 QDSAFSWTDL 650 LIKNNSELLN 660 NLGNFINRAG 670 MFVSKFFGGC 680 VPEMVLTHDD 690 RRLVAHVSWE 700 LQRYHQLLEK 710 VRIRDALRSI 720 LTISRHGNQY 730 IQVNEPWKRI 740 KGDEMDRQRA 750 GTVTGMAVNI 760 AALLSVMLQP 770 YMPTVSSTIQ 780 TQLQLPEAAC 790 RILATSFICT 800 LPAGHRIGTV 810 SPLFQKLEND 820 QIENLRQRFG 830 GGQAKGSPKP 840 AVVEAVTTAG 850 SQDIQVLVDE 860 VTKQGNIVRE 870 LKAQKADKNQ 880 VAAEVAKLLD 890 LKKQLALAEG 900 KPIETPKGKK 910 KKFRLLFWLC 920 RCHPLIFNMC 930 PGAYQSESGT 940 LAQAPPHPSR 950 PPLRSPVAPP 960 PSRPLAREST 970 LSRTRKWLWV TRLRRGGVG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004825 methionine-tRNA ligase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0006431 methionyl-tRNA aminoacylation
Biological Process GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
Biological Process GO:0009303 rRNA transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.