Search Results

Overview

Uniprot ID	D3Z9L5
Protein Name	WD repeat-containing protein 11
Gene Name	Wdr11
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
214	HCSPAHNKLAAATGA

Function

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1

Protein Sequence

10 MLPYTVNFKV 20 SARTLTGALN 30 AHNKAAVDWG 40 WQGLIAYGCH 50 SLVVVIDSNT 60 AQTLQVLEKH 70 KADIVKVKWA 80 RENYHHNIGS 90 PYCLRLASAD 100 VNGKIIVWDV 110 AAGVAQCEIQ 120 EHVKPIQDVQ 130 WLWNQDASRD 140 LLLAIHPPNY 150 IVLWNADTGT 160 KLWKKSYADN 170 ILSFSFDPFD 180 PSHLTLLTSE 190 GIVFISDFSP 200 SKAPSGPGKK 210 VYISSPHCSP 220 AHNKLAAATG 230 AKRALNKVKV 240 LVTQEKPSAE 250 FVALNDCLQL 260 AYLPSKRSHM 270 LLLYPREILI 280 LDLEVNQTVG 290 VIAIERTGVP 300 FLQVIPCSQR 310 DGLFCLHENG 320 CITLRVRRSY 330 SSICTTSSDE 340 PGQSAIAGEE 350 HPKGSILQEV 360 HLKFLLTGLL 370 SGLPSPQFAI 380 RMCPPLTTKN 390 IKMYQPLLAV 400 GTSNGSVLVY 410 HLTSGLLHKE 420 LSVHSCEVKG 430 IEWTSLTSFL 440 SFAASTPNNM 450 GLVRNELQLV 460 DLPTGRSTAF 470 RGDRGNDESP 480 IEMIKVSHLK 490 QYLAVVFKDK 500 PLELWDIRTC 510 TLLREMSKSF 520 PAITALEWSP 530 SHNLKSLRKK 540 QLATREAMAR 550 QTVVSDAELG 560 AVESSVISLL 570 QEAESKSELS 580 QNISAREHFV 590 FTDNDGQVYH 600 LTVEGNSVKD 610 SARIPPDGSM 620 GSITCIAWKG 630 DTLVLGDMDG 640 NLNFWDLKGR 650 VSRGIPTHRS 660 WVRKIRFAPG 670 KGNQKLIAMY 680 TDGAEVWDTK 690 EVQMVSSLRS 700 GRNVTFRILD 710 VDWCTSDKVI 720 LASDDGCIRV 730 LEMSMKSTCF 740 RMDEQELVEP 750 VWCPYLLVPR 760 AALALKAFLL 770 HQPWNGRYSL 780 DISHIDYPEN 790 EEIKTLLQEQ 800 LHALSNDIKK 810 LLLDPEFTLL 820 QRCLLVSRLY 830 GDESELHFWT 840 VAAHYLHSLS 850 QAKSGDTVVT 860 KDGAPKDKLN 870 NPLDICYDVL 880 CENAYFQKFQ 890 LERVNLQEVK 900 RSTYDHTRKC 910 TDQLLLLGQT 920 DRAVQLLLET 930 SADNQHYYCD 940 SLKACLVTTV 950 TSSGPSQSTI 960 KLVATNMIAN 970 GKLAEGVQLL 980 CLIDKAADAC 990 RYLQTYGEWN 1000 RAAWLAKVRL 1010 NSEECADVLK 1020 RWADHLCSPQ 1030 VNQKSKALLV 1040 LLSLGCFVSV 1050 AETLHSMRYF 1060 DRAALFVEAC 1070 LKYGAFGVSE 1080 DTDKLITAIY 1090 TDYARSLKSL 1100 GFKQGAVHFA 1110 SKAGAAGRDL 1120 LNELGSPKEE ATEG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.