Search Results

Overview

Uniprot IDD3Z9Z9
Protein NameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Gene NameSmarcad1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
344 GFNKKRKKNVFNPKK

Function

Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing

Protein Sequence

10 MNLFNLDRFR 20 FEKRSKIEEA 30 PEAAPQPSQP 40 GPSSPISLSA 50 EEENAEGEVS 60 RANTPDSDVT 70 EKTEDSSVPE 80 PPDNESKASL 90 SCFQNQRTIQ 100 EYIDLSSDSE 110 DVSPNCSSTV 120 QEKKFSKDTV 130 IIVSEPSEDE 140 ESHDLPSATR 150 RNDISELEDL 160 SELEDLKDAK 170 LQTLKELFPQ 180 RSDSDLLKLI 190 DSTSTMDGAI 200 AAALLKFGDA 210 GGGPRKRKLS 220 SSSEAYEEDE 230 ANDDQSLKKP 240 RGDRREESNE 250 SAEASSNWEK 260 QESIVLKLQK 270 EFPNFDKQEL 280 REVLKEHEWM 290 YTEALESLKV 300 FAEDQDVQCA 310 SQSEVTNGKE 320 VARNQNYSKN 330 AAKIKMKQKI 340 SMKPQNGFNK 350 KRKKNVFNPK 360 KAVEDSEYDS 370 GSDAGSSLDE 380 DYSSCEEVME 390 DGYKGKILHF 400 LQDASIGELT 410 LIPKCSQKKA 420 QKIIELRPFN 430 NWETLFTKMS 440 KINGLSEDLI 450 WNCKTVIQER 460 DVVIRLMNKC 470 EDISNKLTKQ 480 VTMLTGNGGG 490 WNIEQPSLLN 500 QSLSLKPYQK 510 VGLNWLALVH 520 KHGLNGILAD 530 EMGLGKTIQA 540 IAFLAYLFQE 550 GNKGPHLIVV 560 PASTIDNWLR 570 EVNLWCPTLN 580 VLCYYGSQEE 590 RKQIRFNIHN 600 KYEDYNVIVT 610 TYNCAISSSD 620 DRSLFRRLKL 630 NYAIFDEGHM 640 LKNMGSIRYQ 650 HLMTINARNR 660 LLLTGTPVQN 670 NLLELMSLLN 680 FVMPHMFSSS 690 TSEIRRMFSS 700 KTKPADEQSI 710 YEKERIAHAK 720 QIIKPFILRR 730 VKEEVLKLLP 740 PKKDQIELCA 750 MSEKQEQLYS 760 GLFNRLKKSI 770 NNLEKNTEMC 780 NVMMQLRKMA 790 NHPLLHRQYY 800 TAEKLKEMSQ 810 LMLKEPTHCE 820 ANPDLIFEDM 830 EVMTDFELHV 840 LCKQYQHINS 850 YQLDMDLILD 860 SGKFRTLGCI 870 LSELKQKGDR 880 VVLFSQFTMM 890 LDILEVLLKH 900 HQHRYLRLDG 910 KTQISERIHL 920 IDEFNTDMDI 930 FVFLLSTKAG 940 GLGINLTSAN 950 VVILHDIDCN 960 PYNDKQAEDR 970 CHRVGQTKEV 980 LVIKLISQGT 990 IEESMLKINQ 1000 QKLKLEQDMT 1010 TVDEADEGSM 1020 PADIATLLKT SMGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0043596 nuclear replication fork
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0140674 ATP-dependent histone chaperone activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0140750 nucleosome array spacer activity
Molecular Function GO:0043130 ubiquitin binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0051304 chromosome separation
Biological Process GO:0000729 DNA double-strand break processing
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0000018 regulation of DNA recombination

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.