Search Results
Overview
| Uniprot ID | D3ZAA9 |
|---|---|
| Protein Name | MAGUK p55 subfamily member 2 |
| Gene Name | Mpp2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 351 | RMPPFRRKTLVLIGA |
Function
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (PubMed:27756895). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (By similarity)
Protein Sequence
10
MPVAATNSES
20
AMQQVLDNLG
30
SLPNATGAAE
40
LDLIFLRGIM
50
ESPIVRSLAK
60
AHERLEETKL
70
EAVRDNNLEL
80
VQEILRDLAE
90
LAEQSSTAAE
100
LARILQEPHF
110
QSLLETHDSV
120
ASKTYETPPP
130
SPGLDPTFSN
140
QPVPPDAVRM
150
VGIRKTAGEH
160
LGVTFRVEGG
170
ELVIARILHG
180
GMVAQQGLLH
190
VGDIIKEVNG
200
QPVGSDPRAL
210
QELLRSASGS
220
VILKILPSYQ
230
EPHLPRQVFV
240
KCHFDYDPAR
250
DSLIPCKEAG
260
LRFNAGDLLQ
270
IVNQDDANWW
280
QACHVEGGSA
290
GLIPSQLLEE
300
KRKAFVKRDL
310
ELTPTSGTLC
320
GSLSGKKKKR
330
MMYLTTKNAE
340
FDRHELLIYE
350
EVARMPPFRR
360
KTLVLIGAQG
370
VGRRSLKNKL
380
ILWDPDRYGT
390
TVPYTSRRPK
400
DSEREGQGYS
410
FVSRGEMEAD
420
IRAGRYLEHG
430
EYEGNLYGTR
440
IDSIRGVVAS
450
GKVCVLDVNP
460
QAVKVLRTAE
470
FVPYVVFIEA
480
PDFETLRAMN
490
RAALESGVST
500
KQLTEADLRR
510
TVEESSRIQR
520
GYGHYFDLSL
530
VNSNLERTFR
540
ELQTAMEKLR
550
TEPQWVPVSW
VY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0032590 | dendrite membrane |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0098919 | structural constituent of postsynaptic density |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0060079 | excitatory postsynaptic potential |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0051260 | protein homooligomerization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.