Overview
| Uniprot ID | D3ZB30 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 1 |
|---|
| Gene Name | Ptbp1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 13 |
PDIAVGTKRGSDELF |
| 136 |
FSNHKELKTDSSPNQ |
| 258 |
TLRIDFSKLTSLNVK |
| 265 |
KLTSLNVKYNNDKSR |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
LHSIVPDIAV
20
GTKRGSDELF
30
STCVSNGPFI
40
MSSSASAANG
50
NDSKKFKGDN
60
RSTGVPSRVI
70
HVRKLPSDVT
80
EGEVISLGLP
90
FGKVTNLLML
100
KGKNQAFIEM
110
STEEAANTMV
120
NYYTSVAPVL
130
RGQPIYIQFS
140
NHKELKTDSS
150
PNQARAQAAL
160
QAVNSVQSGN
170
LALAASAAAV
180
DAGMAMAGQS
190
PVLRIIVENL
200
FYPVTLDVLH
210
QIFSKFGTVL
220
KIITFTKNNQ
230
FQALLQYADP
240
VSAQHAKLSL
250
DGQNIYNACC
260
TLRIDFSKLT
270
SLNVKYNNDK
280
SRDYTRPDLP
290
SGDSQPSLDQ
300
TMAAAFGAPG
310
IMSASPYAGA
320
GFPPTFAIPQ
330
AAGLSVPNVH
340
GALAPLAIPS
350
AAAAAAAAGR
360
IAIPGLAGAG
370
NSVLLVSNLN
380
PERLTWVCFQ
390
GVYGDVQRVK
400
ILFNKKENAL
410
VQMADGSQAQ
420
LAMSHLNGHK
430
LHGKSVRITL
440
SKHQSVQLPR
450
EGQEDQGLTK
460
DYGSSPLHRF
470
KKPGSKNFQN
480
IFPPSATLHL
490
SNIPPSVSED
500
DLKSLFSSNG
510
GVVKGFKFFQ
520
KDRKMALIQM
530
GSVEEAVQAL
540
IELHNHDLGE
550
NHHLRVSFSK
STI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.