Search Results
Overview
| Uniprot ID | D3ZBM3 |
|---|---|
| Protein Name | Ferrochelatase |
| Gene Name | Fech |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 56 | AHHAKTTKPQAQPER |
Function
Catalyzes the ferrous insertion into protoporphyrin IX
Protein Sequence
10
MLSAGANMAA
20
ALRAAGALFR
30
EPLVYGSSRA
40
CQPWRCQSGP
50
AVVATTEKAH
60
HAKTTKPQAQ
70
PERRKPKTGI
80
LMLNMGGPET
90
LGEVQDFLQR
100
LFLDRDLMTL
110
PIQNKLAPFI
120
AKRRTPKIQE
130
QYRRIGGGSP
140
IKMWTSKQGE
150
GMVKLLDELS
160
PDTAPHKYYI
170
GFRYVHPLTE
180
EAIEEMERDG
190
LERAIAFTQY
200
PQYSCSTTGS
210
SLNAIYRYYN
220
EVGRKPTMKW
230
STIDRWPTHP
240
LLIQCFADHI
250
LKELDHFPEE
260
KRSEVVILFS
270
AHSLPMSVVN
280
RGDPYPQEVG
290
ATVHRVMEQL
300
GYPNPYRLVW
310
QSKVGPVPWL
320
GPQTDEAIKG
330
LCERGRKNIL
340
LVPIAFTSDH
350
IETLYELDIE
360
YSQVLAQKCG
370
AENIRRAESL
380
NGNPLFSKAL
390
ADLVHSHIQS
400
NKLCSTQLSL
410
SCPLCVNPVC
420
RKTKSFFTSQ
QL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043190 | ATP-binding cassette (ABC) transporter complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0004325 | ferrochelatase activity |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0030350 | iron-responsive element binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0046906 | tetrapyrrole binding |
| Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0009589 | detection of UV |
| Biological Process | GO:0030218 | erythrocyte differentiation |
| Biological Process | GO:0006784 | heme A biosynthetic process |
| Biological Process | GO:0006785 | heme B biosynthetic process |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:0042168 | heme metabolic process |
| Biological Process | GO:0060586 | multicellular organismal-level iron ion homeostasis |
| Biological Process | GO:0006779 | porphyrin-containing compound biosynthetic process |
| Biological Process | GO:0046501 | protoporphyrinogen IX metabolic process |
| Biological Process | GO:0010999 | regulation of eIF2 alpha phosphorylation by heme |
| Biological Process | GO:0046984 | regulation of hemoglobin biosynthetic process |
| Biological Process | GO:0046685 | response to arsenic-containing substance |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0017085 | response to insecticide |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0009416 | response to light stimulus |
| Biological Process | GO:0010038 | response to metal ion |
| Biological Process | GO:0051597 | response to methylmercury |
| Biological Process | GO:0070541 | response to platinum ion |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0034379 | very-low-density lipoprotein particle assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.