Search Results
Overview
| Uniprot ID | D3ZBN0 |
|---|---|
| Protein Name | Histone H1.5 |
| Gene Name | H1-5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | KAGAAKRKATGPPVS |
| 63 | VSLPALKKALAAGGY |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation
Protein Sequence
10
MSETAPAETT
20
APAPVEKSPA
30
KKKTKKAGAA
40
KRKATGPPVS
50
ELITKAVSAS
60
KERGGVSLPA
70
LKKALAAGGY
80
DVEKNNSRIK
90
LGLKSLVSKG
100
TLVQTKGTGA
110
SGSFKLNKKV
120
ASGEAKPKAK
130
KTGAAKAKKP
140
TGATPKKPKK
150
TAGAKKTVKK
160
TPKKAKKPAA
170
AGVKKVTKSP
180
KKAKAAAKPK
190
KATKSPARPK
200
AVKSKASKPK
210
VTKPKAAKPK
220
AAKVKKAVSK
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0050821 | protein stabilization |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.