Search Results
Overview
| Uniprot ID | D3ZC55 |
|---|---|
| Protein Name | Heat shock 70 kDa protein 12A |
| Gene Name | Hspa12a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 336 | RLPEGHLKELYKATG |
| 4 | ****MADKEAGGGDA |
| 427 | SVEHALRKSNVDFVK |
| 549 | LNRYVEGKHPPEKLL |
| 554 | EGKHPPEKLLVKDGT |
| 558 | PPEKLLVKDGTRWCT |
| 664 | AVDIATSKSVKVGID |
Function
Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization
Protein Sequence
10
MADKEAGGGD
20
AGPRETAPTS
30
AYSSPARSLG
40
DTGITPLSPS
50
HILNDADPVS
60
EQQTFLVVVA
70
IDFGTTSSGY
80
AYSFTKEPEC
90
IHVMRRWEGG
100
DPGVSNQKTP
110
TTILLTPERK
120
FHSFGYAARD
130
FYHDLDPNEA
140
KQWLYLEKFK
150
MKLHTTGDLT
160
MDTDLTAANG
170
KKVKALEIFT
180
YALQYFKEQA
190
LKELSDQAGS
200
DFENSDVRWV
210
ITVPAIWKQP
220
AKQFMREAAY
230
QAGLASPENS
240
EQLIIALEPE
250
AASIYCRKLR
260
LHQMIELSSK
270
AVVNGYSASD
280
TVGAGFAQAK
290
EHVRRNRQSR
300
TFLVENVIGE
310
IWSELEEGDK
320
YVVVDSGGGT
330
VDLTVHQIRL
340
PEGHLKELYK
350
ATGGPYGSLG
360
VDYEFEKLLC
370
KIFGEDFIEQ
380
FKIKRPAAWV
390
DLMIAFESRK
400
RAAAPDRTNP
410
LNITLPFSFI
420
DYYKKFRGHS
430
VEHALRKSNV
440
DFVKWSSQGM
450
LRMSPDAMNA
460
LFKPTIDSII
470
EHLRDLFQKP
480
EVSTVKFLFL
490
VGGFAEAPLL
500
QQAVQAAFGD
510
KCRIIIPQDV
520
GLTILKGAVL
530
FGLDPAVIKV
540
RRSPLTYGVG
550
VLNRYVEGKH
560
PPEKLLVKDG
570
TRWCTDVFDK
580
FISADQSVAL
590
GELVKRSYTP
600
AKPSQLVIII
610
NIYSSENDDV
620
SFITDPGVKK
630
CGTLRLDLTG
640
TSGAAVPARR
650
EIQTLMQFGD
660
TEIKATAVDI
670
ATSKSVKVGI
DFLNY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Biological Process | GO:0051170 | import into nucleus |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0042116 | macrophage activation |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.