Search Results

Overview

Uniprot ID	D3ZCG2
Protein Name	Kinesin-like protein KIF21A
Gene Name	Kif21a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
575	EERSVAGKENNADPD
845	QVRPMSDKVAGKVTR

Function

Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex

Protein Sequence

10 MLGAADESSV 20 RVAVRIRPQL 30 AKEKIEGCHI 40 CTSVTPGEPQ 50 VFLGKDKAFT 60 FDYVFDIDSQ 70 QEQIYTQCIE 80 KLIEGCFEGY 90 NATVFAYGQT 100 GAGKTYTMGT 110 GFDVNIMEEE 120 QGIISRAVKH 130 LFKSIEEKKT 140 SAIKNGVPPP 150 EFKVNAQFLE 160 LYNEEVLDLF 170 DTTRDIDAKN 180 KKSNIRIHED 190 STGGIYTVGV 200 TTRTVNTEPE 210 MMQCLKLGAL 220 SRTTASTQMN 230 VQSSRSHAIF 240 TIHVCQTRVC 250 PQTDAENVTD 260 NKMVSESPQM 270 NEFETLTAKF 280 HFVDLAGSER 290 LKRTGATGER 300 AKEGISINCG 310 LLALGNVISA 320 LGDKSKRATH 330 VPYRDSKLTR 340 LLQDSLGGNS 350 QTIMIACVSP 360 SDRDFMETLN 370 TLKYANRARN 380 IKNKVMVNQD 390 RASQQINALR 400 SEITRLQMEL 410 MEYKTGKRII 420 DEEGVESIND 430 MFHENAMLQT 440 ENNNLRVRIK 450 AMQETVDALR 460 ARITQLVSEQ 470 ANQVLARAGE 480 GNEEISNMIH 490 SYIKEIEDLR 500 AKLLESEAVN 510 ENLRKSLTRA 520 TARSPFFSAS 530 SAFSSTILSS 540 DKETIEIIDL 550 AKKDLEKLKR 560 KEKRKKKRLQ 570 KLEESSREER 580 SVAGKENNAD 590 PDQEKKEEKG 600 VSEKESSEVD 610 VDENQEASDH 620 EDEEDEEEED 630 EEEDDIEGEE 640 SSDESDSESD 650 EKANYQADLA 660 NITCEIAIKQ 670 KLIDELENSQ 680 KRLQTLKKQY 690 EEKLMMLQHK 700 IRDTQLERDQ 710 VLQNLGSVES 720 YSEEKAKKVK 730 CEYEKKLHAM 740 NKELQRLQTA 750 QKEHARLLKN 760 QSQYEKQLKK 770 LQQDVTEMKK 780 TKVRLMKQMK 790 EEQEKARLTE 800 SRRNREIAQL 810 KKDQRKRDHQ 820 LRLLEAQKRN 830 QEVVLRRKTE 840 EVTALRRQVR 850 PMSDKVAGKV 860 TRKLSSSESP 870 TPDAGSSVTS 880 GEADASRPGT 890 QQKMRIPVAR 900 VQALPTPTTN 910 GTRKRYQRKG 920 FTGRVFTSKT 930 ARMKWQLLER 940 RVTEIIMQKM 950 TISNMEADMN 960 RLLRQREELT 970 KRREKLSKRR 980 EKIAKESGEG 990 DKNLVNISEE 1000 MESLTANIDY 1010 INDSIADCQA 1020 NIMQMEEAKE 1030 EGETLDVTAV 1040 INACTLTEAR 1050 YLLDHFLSMG 1060 INKGLQAAQK 1070 EAQIKVLEGR 1080 LKQTEITSAT 1090 QNQLLFHMLK 1100 EKAELNPELD 1110 ALLGNALQDL 1120 DSAPLEDEED 1130 SSEEDGPLHS 1140 PGSEGSTLSS 1150 DLMKLCGEVK 1160 PKNKARRRTT 1170 TQMELLYADS 1180 SEVASDTSAG 1190 DASLPGPLTP 1200 VAEGQETGMN 1210 TETSVPSARD 1220 KELLPPSGLP 1230 PKIGSISRQP 1240 SVSEKKVPEP 1250 SPVTRRKAYE 1260 KADKAKTKEQ 1270 KHSDSGASET 1280 SLSPPSSPPS 1290 RPRNELNVFN 1300 RLTVSQGSAP 1310 VQQDKSDESD 1320 PSLSEVHRGI 1330 INPFPACRGI 1340 RASFLQCVHV 1350 AEGHTKAVLC 1360 VDSTDDLLFT 1370 GSKDRTCKVW 1380 NLVTGQEIMS 1390 LGVHPNNVVS 1400 VKYCNYTSLV 1410 FTVSTSYIKV 1420 WDIRESAKCI 1430 RTLTSSGQVT 1440 LGEACSASTS 1450 RTVAIPSGES 1460 QINQIALNPT 1470 GTFLYAASGN 1480 AVRMWDLKRF 1490 QSTGKLTGHL 1500 GPVMCLTVDQ 1510 ISNGQDLIIT 1520 GSKDHYIKMF 1530 DVTEGALGTV 1540 SPTHNFEPPH 1550 YDGIEALAIQ 1560 GDNLFSGSRD 1570 NGIKKWDLAQ 1580 KGLLQQVPNA 1590 HKDWVCALGL 1600 VPGHPILLSG 1610 CRGGILKLWN 1620 VDTFVPVGEM 1630 RGHDSPINAI 1640 SVNSTHVFTA 1650 ADDRTVRIWK 1660 AHNLQDGQIS 1670 DTGDPGEDST SN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0044295	axonal growth cone
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005871	kinesin complex
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0098793	presynapse
Molecular Function	GO:0071532	ankyrin repeat binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0003777	microtubule motor activity
Molecular Function	GO:0008574	plus-end-directed microtubule motor activity
Biological Process	GO:0008089	anterograde axonal transport
Biological Process	GO:0043622	cortical microtubule organization
Biological Process	GO:0007018	microtubule-based movement
Biological Process	GO:1902667	regulation of axon guidance
Biological Process	GO:0031114	regulation of microtubule depolymerization
Biological Process	GO:0031113	regulation of microtubule polymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.