Search Results
Overview
| Uniprot ID | D3ZD11 |
|---|---|
| Protein Name | Signal peptidase complex subunit 2 |
| Gene Name | Spcs2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | AKKVLLEKYKYVENF |
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site
Protein Sequence
10
MAAAASQGGR
20
SGGGGGSSGP
30
GGGPSCGTSS
40
SRSGLLDKWK
50
IDDKPVKIDK
60
WDGSAVKNSL
70
DDSAKKVLLE
80
KYKYVENFGL
90
IDGRLTICTI
100
SCFFAIVALI
110
WDYMHPFPES
120
KPVLALCVVS
130
YFVMMGILTI
140
YTSYKEKSIF
150
LVAHRKDPTG
160
MDPDDIWQLS
170
SSLKRFDDKY
180
TLKLTFISGR
190
TKQQREAEFT
200
KSIAKFFDHS
210
GTLVMDAYEP
220
EISRLHDSLA
TERKIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006465 | signal peptide processing |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005787 | signal peptidase complex |
| Molecular Function | GO:0008233 | peptidase activity |
| Biological Process | GO:0045047 | protein targeting to ER |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.