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Overview

Uniprot ID	D3ZDI9
Protein Name	Ubiquitin carboxyl-terminal hydrolase
Gene Name	Usp13
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
108	ASGGALPKRRNSKLF

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes

Protein Sequence

10 MQRRGALFSV 20 PGGGGKMAAG 30 DLGELLVPHM 40 PTIRVPRSGD 50 RVYKNECAFS 60 YDSPNSEGGL 70 YVCMNTFLAF 80 GREHVERHFR 90 KTGQSVYMHL 100 KRHMREKVRG 110 ASGGALPKRR 120 NSKLFLDLDM 130 DDDLNSDDYE 140 YEDEAKLVIF 150 PDHYEIALPN 160 IEELPALVTI 170 ACDAVLSSKS 180 PYRKQDPDTW 190 ENELPVSKYA 200 NNLVQLDNGV 210 RIPPSGWKCA 220 RCDLRENLWL 230 NLTDGSVLCG 240 KWFFDSSGGN 250 GHALEHYRDM 260 GYPLAVKLGT 270 ITPDGADVYS 280 FQEEGPVSDP 290 HLAKHLAHFG 300 IDMLHTQGTE 310 NGFRDNDIKL 320 RVSEWEVIQE 330 SGTKLKPMYG 340 PGYTGLKNLG 350 NSCYLSSVMQ 360 AIFSIPEFQR 370 AYVGNLPRIF 380 DYSPLDPTQD 390 FNTQMTKLGH 400 GLLSGQYSKP 410 PVKSELIEQV 420 MKEEHKPQQN 430 GISPRMFKAF 440 VSKSHPEFSS 450 NRQQDAQEFF 460 LHLVNLVERN 470 RIGSENPSDV 480 FRFLVEERIQ 490 CCQTRKVRYT 500 ERVDYLMQLP 510 VAMEAATNKD 520 ELIAYELMRR 530 EAETNRRPLP 540 ELVRAKIPFS 550 ACLQAFAEPD 560 NVDDFWSSAL 570 QAKSAGVKTS 580 RFASFPEYLV 590 VQIKKFTFGL 600 DWVPRKFDVS 610 IDMPDLLDIS 620 HLRARGLQPG 630 EEELPDISPP 640 IVIPDDSKDR 650 LMNQLIDPSD 660 IDESSVMQLA 670 EMGFPLEACR 680 KAVYFTGNTG 690 AEVAFNWIIV 700 HMEEPDFAEP 710 LAIPGYGGAG 720 ASAFGATGLD 730 NQPPEEIVAI 740 ITAMGFQRSQ 750 AVQALQATNH 760 NLERALDWIF 770 SHPEFEEDSD 780 FVIEMENNAN 790 ANIMSEAKPE 800 GPRVKDGSGM 810 YELFAFISHM 820 GTSTMSGHYV 830 CHIKKEGRWV 840 IYNDHKVCAS 850 ERPPKDLGYM YFYRRIPS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006914	autophagy
Biological Process	GO:0016579	protein deubiquitination
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0031647	regulation of protein stability

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.