Search Results
Overview
| Uniprot ID | D3ZDU5 |
|---|---|
| Protein Name | Profilin |
| Gene Name | Pfn2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 91 | CTMDIRTKSQGGEPT |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG
Protein Sequence
10
MAGWQSYVDN
20
LMCDGCCQEA
30
AIVGYCDAKY
40
VWAATAGGVF
50
QSITPAEIDV
60
IIGKDREGFF
70
TNGLTLGGKK
80
CSVIRDSLYV
90
DSDCTMDIRT
100
KSQGGEPTYN
110
VAVGRAGRER
120
NTPKNQRTSQ
130
DIPLLLAVST
DCG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0110053 | regulation of actin filament organization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.