Overview
| Uniprot ID | D3ZE15 |
|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
|---|
| Gene Name | Yjefn3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 7 |
*MAASKVKQDMPPPG |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes
Protein Sequence
10
MAASKVKQDM
20
PPPGGYGPID
30
YKRNLPRRGL
40
SGYSMFALGI
50
GALIFGYWRI
60
MRWNRERRRL
70
LIEDLEARIA
80
LMPLLQAEKD
90
RRTLQILREN
100
LEEEAIIMKD
110
VPNWKDALPG
120
VPSTRMKVMQ
130
YSMSQQCLLG
140
SVHPTPPVHT
WKGSEEGC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045271 |
respiratory chain complex I |
| Biological Process |
GO:0022904 |
respiratory electron transport chain |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.