Overview
| Uniprot ID | D3ZE63 |
|---|
| Protein Name | Macrophage migration inhibitory factor |
|---|
| Gene Name | Mifl2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 78 |
IQNRNYSKLLCGLLS |
Function
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
Protein Sequence
10
MPMFIVNTNV
20
PRASVPEGFL
30
SQLTQQLTQA
40
TGKPAQYIAV
50
HVVPDQLMTF
60
SSTNDPCALC
70
SLHSIGKIGG
80
IQNRNYSKLL
90
CGLLSDRLHI
100
SPDRVYINYY
110
DMNAANVGWN
GSTFA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0004167 |
dopachrome isomerase activity |
| Molecular Function |
GO:0050178 |
phenylpyruvate tautomerase activity |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0080135 |
regulation of cellular response to stress |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.