Search Results
Overview
| Uniprot ID | D3ZEI6 |
|---|---|
| Protein Name | Nuclear receptor coactivator 5 |
| Gene Name | Ncoa5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | VDDYCRRKDDSYFDR |
Function
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)
Protein Sequence
10
MNTAPSRPSP
20
TRRDPYSFGD
30
SRDTRRDRSP
40
IRGSPRREPR
50
DGRNGRDTRD
60
RDIRDPRELR
70
DRRDSRDIRD
80
HRDSRSVREA
90
RDLRDFRDFR
100
DLRDSRDFRD
110
HRDPVYDRYR
120
EIRDSRDPLY
130
RREGSYDRYL
140
RVDDYCRRKD
150
DSYFDRYRDS
160
FDGRGPPGPE
170
SQSRAKERLK
180
REERRREELY
190
RRYFEEIQRR
200
FDAERPVDCS
210
VIVVNKQTKD
220
YAESVGRKVR
230
DLGMVVDLIF
240
LNTEVSLSQA
250
LEDVSRGGSP
260
FAIVITQQHQ
270
IHRSCTVNIM
280
FGTPQEHRNM
290
PQADAMVLVA
300
RNYERYKNDC
310
REKEREEIAR
320
QAAKMANDAI
330
LQERDRGGPE
340
EGGRGGHPPA
350
IQSLINLLAD
360
NRYLTAEETD
370
KIINYLRERK
380
ERLLRSSADS
390
LPGPISRQPL
400
GAASGSSLKT
410
QPSSQPLQSG
420
QVLPSATPTP
430
AAPPTSQQEL
440
QAKILSLFNS
450
GAVAANSSSA
460
SPSVATGSSQ
470
NQNFSTAANS
480
QPQQRPQASG
490
NQPPNIVGQA
500
GSARNMGPRP
510
GAPSQGLFGQ
520
PSSRLAPASN
530
MASQRPVSST
540
GINFDNPSVQ
550
KALDTLIQSG
560
PALSHLVSQT
570
AAQVGRPQAP
MGSYQRHY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003682 | chromatin binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:0009966 | regulation of signal transduction |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.