Search Results

Overview

Uniprot ID	D3ZEM8
Protein Name	Pre-rRNA-processing protein TSR1 homolog
Gene Name	Tsr1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
10	AHRSGPLKQQNKAHK

Function

Required during maturation of the 40S ribosomal subunit in the nucleolus

Protein Sequence

10 MAAHRSGPLK 20 QQNKAHKGGR 30 HHGGGSAQRD 40 SKGRVGPKIL 50 CKKLKKQLSR 60 VDQRHRASQL 70 RKQKREAVRS 80 GGWEAVLAEK 90 RQLGSKDGPP 100 HQVLVVPLHN 110 RICLPEAFKL 120 LQNEDLGTVY 130 LNERGSTHSF 140 MLLSPSLKHR 150 WSFTYARPGD 160 LHTLLDMAKV 170 ADTILFLLDP 180 LEGWDSTGDY 190 CLSCLFAQGL 200 PTYMLAVQGL 210 PSLPPKRQTD 220 ARKKLNKTVE 230 KRFPEDKLLL 240 LDTQQESGML 250 LRQLANQKQR 260 HLAFRDRRAY 270 LFAHDADFMP 280 SEESDLVGTL 290 KISGYIRGRT 300 LNVNSLLHIV 310 GHGDFQMNQI 320 DAPVDPFPLN 330 PRVVKSQKKP 340 SMSMEVCVTD 350 AAADMEEGLK 360 VLMKADPDQQ 370 ETLQTEVIPD 380 PMEGEQTWPT 390 EEELDEANDS 400 LKQRSRVVKK 410 VPKGTSNYQA 420 EWILDEGDES 430 DGEGDESDDD 440 IQHEGFMEEE 450 SQDGSGEEEE 460 EECETMTLGE 470 SVRDDLYDEK 480 VDEEDEERML 490 EKYKQERLEE 500 MFPDEMDTPR 510 DVAARIRFQK 520 YRGLKSFRTS 530 PWDPKENLPR 540 DYARIFQFQN 550 FVNTRKRIFK 560 EIEEKETEGA 570 EVGWYVTLHV 580 SNVPVSVVES 590 FRQGAPLIAF 600 SLLPYEQKMS 610 VLNMVVSRSP 620 GNTEPVKAKE 630 ELIFHCGFRR 640 FRASPLFSQH 650 TAADKHKFQR 660 FLTADAALVV 670 TVFAPITFPP 680 ASVLLFKQRR 690 NGMHSLIATG 700 HLFSVDPDRM 710 VIKRVVLSGH 720 PFKIFTKTAV 730 VRYMFFSRDD 740 VLWFKPVELR 750 TKWGRRGHIK 760 EPLGTHGHMK 770 CSFDGKLKSQ 780 DTVLMNLYKR 790 VFPKWTYDPY 800 VPEPVLWVKS 810 DISSTVSEVD ME

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030686	90S preribosome
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.