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Overview

Uniprot ID	D3ZES7
Protein Name	Plexin-A4
Gene Name	Plxna4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1619	VSRTSASKYENMIRY

Function

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm

Protein Sequence

10 MKAMPWNWTC 20 LLSHLLVVGM 30 GSSTLLPRQP 40 PQMSQKPSFV 50 TFRGEPTEGF 60 NHLVVDERTG 70 HIYLGAVNRI 80 YKLSSDLKVL 90 VTHQTGPDED 100 NPKCYPPRIV 110 QTCNEPLAST 120 NNVNKMLLID 130 YKENRLIACG 140 SLYQGICKLL 150 RLEDLFKLGE 160 PFHKKEHYLS 170 GVNESGSVFG 180 VIVSYSNFDD 190 KLFIATAVDG 200 KPEYFPTISS 210 RKLTKNSEAD 220 GMFAYVFHDE 230 FVASMIKIPS 240 DTFTVIPDFD 250 IYYVYGFSSG 260 NFVYFLTLQP 270 EMVSPPGSTT 280 KEQVYTSKLV 290 RLCKEDTAFN 300 SYVEVPIGCE 310 RSGVEYRLLQ 320 AAYLSKAGAV 330 LGRTLGVRPD 340 DDLLFTVFSK 350 GQKRKMKSLD 360 ESALCVFILK 370 QINDRIKDRL 380 QSCYRGEGTL 390 DLAWLKVKDI 400 PCSSALLTID 410 DNFCGLDMNA 420 PLGVSEMVRG 430 IPVFTEDRDR 440 MTSVIAYVYK 450 NHSLAFVGTK 460 SGKLKKIRVD 470 GPKGNALQYE 480 TVQVVDSGPV 490 LRDMAFSKDH 500 EQLYIMSERQ 510 LTRVPVESCG 520 QYRSCGECLG 530 SGDPHCGWCV 540 LHNTCTRKER 550 CERSREPRRF 560 ASEMKQCVRL 570 TVHPNNISVS 580 QYNVLLVLET 590 YNVPELSAGV 600 NCTFEDLSEM 610 DGLVIGNQIQ 620 CYSPAAKEVP 630 RIITENGDHH 640 VVQLQLKSKE 650 TGMTFASTSF 660 VFYNCSVHNS 670 CLSCVESPYR 680 CHWCKYRHVC 690 THDPKTCSFQ 700 EGRVKLPEDC 710 PQLLRVDKIL 720 VPVEVIKPIT 730 LKAKNLPQPQ 740 SGQRGYECIL 750 NIQGMEQRVP 760 ALRFNSSSVQ 770 CQNTSYSYEG 780 MEINNLPVEL 790 TVVWNGHFNI 800 DNPAQNKVYL 810 YKCGAMRESC 820 GLCLKADPDF 830 ECGWCQSPGQ 840 CTLRQHCPAH 850 ESRWLELSGA 860 NSKCTNPRIT 870 EIIPVTGPRE 880 GGTKVTIRGE 890 NLGLEFRDIA 900 SHVKVAGVEC 910 IPLVDGYIPA 920 EQIVCEMGEA 930 KPSQHAGFVE 940 ICVAVCRPEF 950 MARSSQLYYF 960 MTLTLADLKP 970 NRGPMSGGTQ 980 VTITGTNLNA 990 GSNVVVMFGS 1000 QPCLFHRRSP 1010 SYIICNTTSS 1020 EEVLDMKVTV 1030 QVDRARIRQD 1040 LVFQYVEDPT 1050 IVRIEPEWSI 1060 VSGNTPIAVW 1070 GTHLDLIQNP 1080 QIRAKHGGKE 1090 HINICEVLNA 1100 TEMTCQAPAL 1110 ALGPDHQSDL 1120 TERPEEFGFI 1130 LDNVQSLLIL 1140 NKTNFTYYPN 1150 PVFEAFSPSG 1160 ILELKPGTPI 1170 ILKGKNLIPP 1180 VAGGNVKLNY 1190 TVLVGEKPCT 1200 VTVSDVQLLC 1210 ESPNLIGRHK 1220 VMARVGGMEY 1230 SPGMVYIAPD 1240 SPLSLPAIVS 1250 IAVAGGLLII 1260 FIVAVLIAYK 1270 RKSRESDLTL 1280 KRLQMQMDNL 1290 ESRVALECKE 1300 AFAELQTDIH 1310 ELTSDLDGAG 1320 IPFLDYRTYT 1330 MRVLFPGIED 1340 HPVLRDLEVP 1350 GYRQERVEKG 1360 LKLFAQLINN 1370 KVFLLSFIRT 1380 LESQRSFSMR 1390 DRGNVASLIM 1400 TVLQSKLEYA 1410 TDVLKQLLAD 1420 LIDKNLESKN 1430 HPKLLLRRTE 1440 SVAEKMLTNW 1450 FTFLLYKFLK 1460 ECAGEPLFSL 1470 FCAIKQQMEK 1480 GPIDAITGEA 1490 RYSLSEDKLI 1500 RQQIEYKTLV 1510 LSCVSPDNAN 1520 SPEVPVKILN 1530 CDTITQVKEK 1540 ILDAIFKNVP 1550 CSHRPKAADM 1560 DLEWRQGSGA 1570 RMILQDEDIT 1580 TKIENDWKRL 1590 NTVAHYQVPD 1600 GSLVALVSKQ 1610 VTAYNAVNNS 1620 TVSRTSASKY 1630 ENMIRYTGSP 1640 DSLRSRTPMI 1650 TPDLESGVKL 1660 WHLVKNHEHG 1670 DQKEGDRGSK 1680 MVSEIYLTRL 1690 LATKGTLQKF 1700 VDDLFETIFS 1710 TAHRGSALPL 1720 AIKYMFDFLD 1730 EQADKHGIHD 1740 PHVRHTWKSN 1750 CLPLRFWVNM 1760 IKNPQFVFDI 1770 HKNSITDACL 1780 SVVAQTFMDS 1790 CSTSEHRLGK 1800 DSPSNKLLYA 1810 KDIPSYKNWV 1820 ERYYSDIGKM 1830 PAISDQDMNA 1840 YLAEQSRMHM 1850 NEFNTMSALS 1860 EIFSYVGKYS 1870 EEILGPLDHD 1880 DQCGKQKLAY 1890 KLEQVITLMS LDS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0002116	semaphorin receptor complex
Molecular Function	GO:0017154	semaphorin receptor activity
Biological Process	GO:0021960	anterior commissure morphogenesis
Biological Process	GO:0007411	axon guidance
Biological Process	GO:0021785	branchiomotor neuron axon guidance
Biological Process	GO:0021793	chemorepulsion of branchiomotor axon
Biological Process	GO:0021602	cranial nerve morphogenesis
Biological Process	GO:0035050	embryonic heart tube development
Biological Process	GO:0021610	facial nerve morphogenesis
Biological Process	GO:0021612	facial nerve structural organization
Biological Process	GO:0021615	glossopharyngeal nerve morphogenesis
Biological Process	GO:0099558	maintenance of synapse structure
Biological Process	GO:0008045	motor neuron axon guidance
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0048812	neuron projection morphogenesis
Biological Process	GO:0021784	postganglionic parasympathetic fiber development
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance
Biological Process	GO:0030334	regulation of cell migration
Biological Process	GO:0050923	regulation of negative chemotaxis
Biological Process	GO:0120035	regulation of plasma membrane bounded cell projection organization
Biological Process	GO:0071526	semaphorin-plexin signaling pathway
Biological Process	GO:0048485	sympathetic nervous system development
Biological Process	GO:0097492	sympathetic neuron axon guidance
Biological Process	GO:0007416	synapse assembly
Biological Process	GO:0021636	trigeminal nerve morphogenesis
Biological Process	GO:0021637	trigeminal nerve structural organization
Biological Process	GO:0021644	vagus nerve morphogenesis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.