Search Results
Overview
| Uniprot ID | D3ZFB6 |
|---|---|
| Protein Name | Proline-rich transmembrane protein 2 |
| Gene Name | Prrt2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 225 | APPRVLQKLVEEDRI |
Function
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation
Protein Sequence
10
MAASSSEVSE
20
MKGVEDSSNT
30
HSEGPRHSEE
40
GMGPVQVVAE
50
NLDQPEALQS
60
GPDTTAAPVD
70
SGPKAELAPE
80
TTETPVETPE
90
TVQATDLSVN
100
PGEDSKTCPS
110
PKEACQEPAS
120
RPEVNREATA
130
EQGAEQQSAA
140
PPEPTSEQAL
150
QLNTQSDPQP
160
TSQPPPKPPL
170
QAEPPTQENP
180
TTEVLTESTG
190
EKQENGAVVP
200
LQAGDGEEGP
210
APQPHSPPST
220
KTPPANGAPP
230
RVLQKLVEED
240
RIGRAHGGHP
250
GSPRGSLSRH
260
PSSQLAGPGV
270
EGGEGTQKPR
280
DYIILAILSC
290
FCPMWPVNIV
300
AFAYAVMSRN
310
SLQQGDVDGA
320
QRLGRVAKLL
330
SIVALVGGVL
340
IIIASCVINL
GVYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:1905513 | negative regulation of short-term synaptic potentiation |
| Biological Process | GO:0035544 | negative regulation of SNARE complex assembly |
| Biological Process | GO:0050884 | neuromuscular process controlling posture |
| Biological Process | GO:0150037 | regulation of calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.