Search Results

Overview

Uniprot IDD3ZFD0
Protein NameUnconventional myosin-XVIIIa
Gene NameMyo18a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
719 AIFKHQLKGGTLQRS

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity (By similarity)

Protein Sequence

10 MFNLMKKDKD 20 KDGGRKEKKE 30 KKEKKERMSA 40 AELRSLEEMS 50 MRRGFFNLNR 60 SSKRESKTRL 70 EISNPIPIKV 80 ASGSDLHLTD 90 IDSDSNRGSI 100 ILDSGHLSTA 110 SSSDDLKGEE 120 GSFRGSVLQR 130 AAKFGSLAKQ 140 NSQMIVKRFS 150 FSQRSRDESA 160 SETSTPSEHS 170 AAPSPQVEVR 180 TLEGQLMQHS 190 GLGIPRPGPR 200 SRVPELVTKR 210 FPADLRLPAL 220 VPPPPPALRE 230 LELQRRPTGD 240 FGFSLRRTTM 250 LDRAPEGQAY 260 RRVVHFAEPG 270 AGTKDLALGL 280 VPGDRLVEIN 290 GQNVENKSRD 300 EIVEMIRQSG 310 DSVRLKVQPI 320 PELSELSRSW 330 LRTGEGHRRE 340 PTDAKTEEQI 350 AAEEAWYETE 360 KVWLVHRDGF 370 SLASQLKSEE 380 LSLPEGKVRV 390 KLDHDGAILD 400 VDEDDVEKAN 410 APSCDRLEDL 420 ASLVYLNESS 430 VLHTLRQRYG 440 ASLLHTYAGP 450 SLLVLSPRGA 460 PAVYSEKVMH 470 MFKGCRREDM 480 APHIYAVAQT 490 AYRAMLMSRQ 500 DQSIVLLGSS 510 GSGKTTSSQH 520 LVQYLATIAG 530 TSGNKVFSVE 540 KWQALATLLE 550 AFGNSPTIMN 560 GSATRFSQIL 570 SLDFDQAGQV 580 ASASVQTMLL 590 EKLRVARRPA 600 SEATFNVFYY 610 LLACGDSTLR 620 TELHLNHLAE 630 NNVFGIVPLS 640 KPEEKQRAAQ 650 QFSKLQTAMK 660 VLAISPEEQK 670 ACWLILASIY 680 HLGAAGATKA 690 VFSCGRKQFA 700 RHEWAQKAAY 710 LLGCSLEELS 720 SAIFKHQLKG 730 GTLQRSTSFR 740 QGPEESGLGE 750 GTGTKLSALE 760 CLEGMASGLY 770 SELFTLLISL 780 VNRALKSSQH 790 SLCSMMIVDT 800 PGFQNPEWGG 810 SARGASFEEL 820 CHNYAQDRLQ 830 KLFHERTFLQ 840 ELERYKEDNI 850 ELAFDDLEPV 860 TDDSVAAVDQ 870 ASHQSLVRSL 880 AHADEARGLL 890 WLLEEEALVP 900 GATEDTLLDR 910 LFSYYGPQEG 920 DKKGQSPLLR 930 SSKPRHFLLG 940 HSHGTNWVEY 950 NVTGWLNYTK 960 QNPATQNAPR 970 LLQDSQNSVV 980 ECLPSKRKAL 990 GSVLSSEKKK 1000 RKKKKKKKCP 1010 ESANSVAHTY 1020 SLSTQTLQVD 1030 ALIDTIKRSK 1040 MHFVHCFLPV 1050 AEGWPGEPRS 1060 ASSRRVSSSS 1070 ELDLPPGDPC 1080 EAGLLQLDVS 1090 LLRAQLRGSR 1100 LLDAIRMYRQ 1110 GYPDHMVFSE 1120 FRRRFDVLAP 1130 HLTKKHGRNY 1140 IMVDEKRAVE 1150 ELLESLDLEK 1160 SSCCMGLSRV 1170 FFRAGTLARL 1180 EEQRDEETSR 1190 HLTLFQAACR 1200 GYLARQHFKK 1210 RKIQDLAIRC 1220 VQKNIKKNKG 1230 VKDWPWWKLF 1240 TTVRPLIQVQ 1250 LSEEQIRNKD 1260 EEIQQLRNKL 1270 EKVEKERNEL 1280 RLNSDRLETR 1290 ISELTSELTD 1300 ERNTGESASQ 1310 LLDAETAERL 1320 RTEKEMKELQ 1330 TQYDALKKQM 1340 EAMDMEVMEA 1350 RLIRAAEING 1360 EVDDDDAGGE 1370 WRLKYERAVR 1380 EVDFTKKRLQ 1390 QELEDKMEVE 1400 QQNRRQLERR 1410 LGDLQADSDE 1420 SQRALQQLKK 1430 KCQRLTAELQ 1440 DTKLHLEGQQ 1450 VRNHELEKKQ 1460 RRFDSELSQA 1470 HEETQREKLQ 1480 REKLQREKDM 1490 LLAEAFSLKQ 1500 QMEEKDLDIA 1510 GFTQKVVSLE 1520 AELQDISSQE 1530 SKDEASLAKV 1540 KKQLRDLEAK 1550 VKDQEEELDE 1560 QAGSIQMLEQ 1570 AKLRLEMEME 1580 RMRQTHSKEM 1590 ESRDEEVEEA 1600 RQSCQKKLRQ 1610 MEVQLEEEYE 1620 DKQKALREKR 1630 ELESKLSTLS 1640 DQVNQRDFES 1650 EKRLRKDLKR 1660 TKALLADAQI 1670 MLDHLKNNAP 1680 SKREIAQLKN 1690 QLEESEFTCA 1700 AAVKARKAME 1710 VEMEDLHLQI 1720 DDIAKAKTAL 1730 EEQLSRLQRE 1740 KNEIQNRLEE 1750 DQEDMNELMK 1760 KHKAAVAQAS 1770 RDMAQMNDLQ 1780 AQLEESNKEK 1790 QELQEKLQAL 1800 QSQVEFLEQS 1810 MVDKSLVSRQ 1820 EAKIRELETR 1830 LEFEKTQVKR 1840 LESMASRLKE 1850 NMEKLTEERD 1860 QRAAAENREK 1870 EQNKRLQRQL 1880 RDTKEEMSEL 1890 ARKEAEASRK 1900 KHELEMDLES 1910 LEAANQSLQA 1920 DLKLAFKRIG 1930 DLQAAIEDEM 1940 ESDENEDLIN 1950 SLQDMVTKYQ 1960 KRKNKLEGDS 1970 DVDSELEDRV 1980 DGVKSWLSKN 1990 KGPSKAPSDD 2000 GSLKSSSPTS 2010 HWKSLAPDLS 2020 DDEHDPVDSI 2030 SRPRFSHNYL 2040 SDSDTEAKLT ETNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042641 actomyosin
Cellular Component GO:0005903 brush border
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003774 cytoskeletal motor activity
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0090164 asymmetric Golgi ribbon formation
Biological Process GO:0007249 canonical NF-kappaB signal transduction
Biological Process GO:0016477 cell migration
Biological Process GO:0071346 cellular response to type II interferon
Biological Process GO:0007030 Golgi organization
Biological Process GO:0090161 Golgi ribbon formation
Biological Process GO:0048194 Golgi vesicle budding
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:1903028 positive regulation of opsonization
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0043030 regulation of macrophage activation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.