Search Results

Overview

Uniprot IDD3ZFG7
Protein NameZinc finger protein 462
Gene NameZfp462
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
106 PNPKPTNKFFQCKFC
656 SSSNTVKKSQTSILG

Function

Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation

Protein Sequence

10 MEVLQCDGCD 20 FRAPSYEDLK 30 AHIQDVHTAF 40 LQPTDVAEDN 50 DDEPLSGSVN 60 AGNQTEVEFS 70 SIKDEFVIAE 80 DLSGQSATAL 90 GSGSYYGHSP 100 GYYGQHITPN 110 PKPTNKFFQC 120 KFCVRYFRSK 130 NLLIEHTRKV 140 HGAQAEESPT 150 GPPVPGSLNY 160 NIMMHEGFGK 170 VFSCQFCTYK 180 SPRRARIIKH 190 QKMYHKNSLK 200 ESAAPPPAPA 210 PLSDPVVPPV 220 SLQDPCKELP 230 AEVVERSILE 240 SMVKPLTKSR 250 GNFCCEWCSY 260 QTPRRERWCD 270 HMMKKHRSMV 280 KILSNIRQQQ 290 EGTNVSEVQN 300 NNEPSPTSNS 310 TYLSMNAASR 320 EMPNTNVSNF 330 RGSVGNSIMR 340 PNSSSTSKFS 350 PMSYPQMKPK 360 SPHNSGLVNL 370 TERSRYGMSD 380 MTNSSADLDT 390 NSMLNDSSSD 400 EDLNEVDSEN 410 GLSVMDHQAS 420 GLSAEQLMGS 430 DGNKLLETKG 440 IPFRRFMNRF 450 QCPFCPFLTM 460 HRRSISRHIE 470 NIHLSGKTAV 480 YKCDECPFTC 490 KSSLKLGAHK 500 QCHTGTSDWD 510 TVNSQSESLS 520 SSLNEGMLSY 530 ESPSINGRKS 540 GVMLDPLQQQ 550 QPPQPPPPLP 560 PPPPPPSQPV 570 QQPPPPQLQS 580 PHQVPPQPQP 590 PPPTQQPQPP 600 TQVPPLHPYK 610 CTMCSYSTMT 620 LKGLRVHQQH 630 KHSFCDNLPK 640 FEGQPSSLPL 650 ENETDSHPSS 660 SNTVKKSQTS 670 ILGLSSKNNF 680 VAKASRKLAN 690 DFPLDLSPVK 700 KRTRIDEIAS 710 NLQSKINQTK 720 LQEDAIINVE 730 DDEEEEDDNE 740 VEIEVELDRE 750 EEPTEPIMDV 760 PTAFSAQQIW 770 ARDTSESQKE 780 ANYRSITHDY 790 TATNGAEIEL 800 TLSEDEEDYY 810 GSSTSIKDHQ 820 VSNAALLNTQ 830 PPIYGTEHSN 840 ENTDFGDSGR 850 LYYCKHCDFN 860 NKSARSVSTH 870 YQRMHPYIKF 880 SFRYILDPND 890 HSAVYRCLEC 900 YIDYTNFEDL 910 QQHYGEHHPE 920 AMNVLNFDHS 930 DLIYRCRFCS 940 YTSPNVRSLM 950 PHYQRMHPTV 960 KINNAMIFSS 970 YVVEQQEGLN 980 AESQTLREIL 990 NSAPKSMATS 1000 TPVARGGGMP 1010 ATFNKNTSPK 1020 TFTPECENQK 1030 DPSVNTVVVY 1040 DCDVCSFASP 1050 NMHSVLVHYQ 1060 KKHPEEKASY 1070 FRIQKTMRMV 1080 SVDRGSALAQ 1090 LSFEVGAPMS 1100 PKMSNMGSPP 1110 PPQPPPPDLS 1120 IELYYCKHCS 1130 YSNRSVVGVL 1140 VHYQKRHPEI 1150 KVTAKYIRQA 1160 PPTAAMMRGA 1170 EGLQDSPRPP 1180 APMQLNRSSS 1190 ERDCPPVETE 1200 MFFCQHCDYG 1210 NRTVKGVLIH 1220 YQKKHRDFKA 1230 NADVIRQHTA 1240 TIRSLCDRNQ 1250 KPASCVLLPA 1260 SGMERDKTKL 1270 RALKCRQCSY 1280 TSPYFYALRK 1290 HIKKDHPALK 1300 ATVTSIMRWA 1310 FLDGLIEAGY 1320 HCEWCIYSHM 1330 EPSGLLLHYQ 1340 RRHPEHYVDY 1350 TYMATKLWAG 1360 PDPSSPTLTM 1370 SAEAKTYRCR 1380 DCAFEAVSIW 1390 DITNHYQAFH 1400 PWAMNGDESV 1410 LLDIIKEKDG 1420 VDKALLAPEE 1430 LIGAVNCENS 1440 LPNPLPEQEA 1450 ECPEDARLSP 1460 EKSIHLASAN 1470 PAISSTPYQC 1480 TVCQSEYNNL 1490 HGLLTHYGKK 1500 HPGMKVKAAD 1510 FAQDVDINPG 1520 AVYKCRHCPY 1530 INTRIHGVLT 1540 HYQKRHPAIK 1550 VTAEDFVHDV 1560 EQSADITQND 1570 VEETSRIFKQ 1580 GYGAYRCKLC 1590 PYTHGTLEKL 1600 KIHYEKYHNQ 1610 PEFDVFSPSP 1620 PKLPVSLEPE 1630 ITTEVSPSQV 1640 SMTEEEVGED 1650 PMSTAHFSTS 1660 HLVSHTVFRC 1670 QLCKYFCSTR 1680 KGIARHYRIK 1690 HNNVRAQPEG 1700 KNNLFKCALC 1710 AYTNPIRKGL 1720 AAHYQKRHDI 1730 DAYYTHCLAA 1740 SRTISDKPNK 1750 VIIPSPPKDD 1760 SPQLSEELRR 1770 AVEKKKCSLC 1780 SFQSFSKKGI 1790 VSHYMKRHPG 1800 VFPKKQHASK 1810 LGGYFTAVYA 1820 DEHEKPPLME 1830 EEGRSGFERP 1840 EVEGEAQDIE 1850 WLPFRCIKCF 1860 KLSFSTAELL 1870 CMHYTDHHSR 1880 DLKRDFVILG 1890 SGPRFQNSTF 1900 QCKHCDSKLQ 1910 STAELTSHLN 1920 IHNEEFQKRA 1930 KRQERRKQLL 1940 SKQKYADGAF 1950 ADFKQERPFG 1960 HLEEAPKIKE 1970 RKVVGYKCKF 1980 CVEVHPTLRA 1990 ICNHLRKHVQ 2000 YGSVPAVSAA 2010 VKQEAEDPSH 2020 LFLDGFEAAR 2030 DASGTLGLRS 2040 HERSHLALAM 2050 FTREDKYSCQ 2060 YCSFVSAFRH 2070 NLDRHMQTHH 2080 GHHKPFRCKL 2090 CSFKSSYNSR 2100 LKTHILKAHA 2110 GEHAYKCSWC 2120 SFSTMTISQL 2130 KEHSLKVHGK 2140 ALTLPRPRIV 2150 SLLSSHAHHS 2160 SQKATPAEEV 2170 EDSNDSSYSE 2180 PPDVQQQLNH 2190 YQSAALARNN 2200 SRVSPVPPSG 2210 TAAGTEQKAE 2220 AVLHCEFCEF 2230 SSGYIQSIRR 2240 HYRDKHGGKK 2250 LFKCKDCSFY 2260 TGFKSAFTMH 2270 VEAGHSAVPE 2280 EGPKDLRCPL 2290 CLYHTKYKRN 2300 MIDHIVLHRE 2310 ERVVPIEVCR 2320 SKLSKYLQGV 2330 VFRCDKCTFT 2340 CSSDESLQQH 2350 IEKHNELRPY 2360 KCQLCYYETK 2370 HTEELDTHLR 2380 DEHKVSRNFE 2390 LVGRVNLDQL 2400 EQMKEKMESS 2410 SSDDEDKDDE 2420 MSSKTEDREL 2430 MRFSDRGAGV 2440 NTEKRFPCEF 2450 CGRAFSQGSE 2460 WERHVLRHGM 2470 ALHDTDQVSR 2480 DEIHTKEMVE 2490 DSMQLPSIEA 2500 KEDDEPIGID 2510 FPLKSETVTI 2520 CVVAADKSLL ENAEAKTE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.