Search Results

Overview

Uniprot IDD3ZGE6
Protein NameSrc substrate cortactin
Gene NameCttn
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
107 VGHEYQSKLSKHCSQ
110 EYQSKLSKHCSQVDS
124 SVRGFGGKFGVQMDR
144 VGFEYQGKTEKHASQ
152 TEKHASQKDYSSGFG
161 YSSGFGGKYGVQADR
171 VQADRVDKSAVGFDY
181 VGFDYQGKTEKHESQ
189 TEKHESQKDYSKGFG
193 ESQKDYSKGFGGKYG
198 YSKGFGGKYGIDKDK
208 IDKDKVDKSAVGFEY
226 TEKHESQKDYVKGFG
230 ESQKDYVKGFGGKFG
235 YVKGFGGKFGVQTDR
245 VQTDRQDKCALGWDH
263 LQLHESQKVMFLTLS
283 YKTGFGGKFGVQSER
42 KEQRWGAKTVQGSGH
70 FQEHQTLKEKELETG
79 KELETGPKASHGYGG
87 ASHGYGGKFGVEQDR
97 VEQDRMDKSAVGHEY

Function

Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane

Protein Sequence

10 MWKASAGHAV 20 SITQDDGGAD 30 DWETDPDFVN 40 DVSEKEQRWG 50 AKTVQGSGHQ 60 EHINIHKLRE 70 NVFQEHQTLK 80 EKELETGPKA 90 SHGYGGKFGV 100 EQDRMDKSAV 110 GHEYQSKLSK 120 HCSQVDSVRG 130 FGGKFGVQMD 140 RVDQSAVGFE 150 YQGKTEKHAS 160 QKDYSSGFGG 170 KYGVQADRVD 180 KSAVGFDYQG 190 KTEKHESQKD 200 YSKGFGGKYG 210 IDKDKVDKSA 220 VGFEYQGKTE 230 KHESQKDYVK 240 GFGGKFGVQT 250 DRQDKCALGW 260 DHQEKLQLHE 270 SQKVMFLTLS 280 RGSPDYKTGF 290 GGKFGVQSER 300 QDSSAVGFDY 310 KEKLAKHESQ 320 QDYAKGFGGK 330 YGVQKDRMDK 340 NASTFEEVVQ 350 VPSAYQKTVP 360 IEAVTSKTSN 370 IRANFENLAK 380 EREQEDRRKA 390 EAERAQRMAQ 400 ERQEQEEARR 410 KLEEQARAKK 420 QTPPASPSPQ 430 PAEDRPPSSP 440 IYEDAAPLKA 450 EPSYGSSEPE 460 PEYSTEAAGL 470 PEASNQQGLA 480 YTSEPVYETT 490 EVPGHYQAED 500 DTYDGYESDL 510 GITAIALYDY 520 QAAGDDEISF 530 DPDDVITNIE 540 MIDDGWWRGV 550 CKGRYGLFPA NYVELRQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008076 voltage-gated potassium channel complex
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0030863 cortical cytoskeleton
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:1990023 mitotic spindle midzone
Cellular Component GO:0002102 podosome
Cellular Component GO:0001726 ruffle
Molecular Function GO:0005522 profilin binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0045987 positive regulation of smooth muscle contraction
Biological Process GO:1901524 regulation of mitophagy

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.