Search Results

Overview

Uniprot IDD3ZHV2
Protein NameMicrotubule-actin cross-linking factor 1
Gene NameMacf1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
5310 VISSTGSKLKRPTPT

Function

F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (By similarity). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (By similarity). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity)

Protein Sequence

10 MSSSDEETLS 20 ERSCRSERSC 30 RSERSYRSER 40 SGSLSPCPPG 50 DTLPWNLPLH 60 EQKKRKSQDS 70 VLDPAERAVV 80 RVADERDRVQ 90 KKTFTKWVNK 100 HLMKVRKHIN 110 DLYEDLRDGH 120 NLISLLEVLS 130 GIKLPREKGR 140 MRFHRLQNVQ 150 IALDFLKQRQ 160 VKLVNIRNDD 170 ITDGNPKLTL 180 GLIWTIILHF 190 QISDIYISGE 200 SGDMSAKEKL 210 LLWTQKVTAG 220 YTGIKCTNFS 230 SCWSDGKMFN 240 ALIHRYRPDL 250 VDMERVQIQS 260 NRENLEQAFE 270 VAERLGVTRL 280 LDAEDVDVPS 290 PDEKSVITYV 300 SSIYDAFPKV 310 PEGGEGISAT 320 EVDSRWQEYQ 330 SRVDSLIPWI 340 RQHTILMSDK 350 SFPQNPVELK 360 ALYNQYIHFK 370 ETEILAKERE 380 KGRIKELYKL 390 LEVWIEFGRI 400 KLPQGYHPNH 410 VEEEWGKLIV 420 EMLEREKSLR 430 PAVERLELLL 440 QIANKIQNGA 450 LNCEEKLTLA 460 KNTLQADAAH 470 LESGQPVQCE 480 SDVIMYIQEC 490 EGLIRQLQVD 500 LQILRDEKYY 510 QLEELAFRVM 520 RLQDELVTLR 530 LECTNLYRKG 540 HFTSLELVPP 550 STLTTTHLKA 560 EPLNKTTHSS 570 STSWFRKPMT 580 RTELVAISSS 590 EDEGSLRFVY 600 ELLSWVEEMQ 610 MKLERAEWGN 620 DLPSVELQWE 630 TQQHIHTSVE 640 ELGSSVKEAR 650 LYEGKMSQNF 660 HTSYVETLGK 670 LETQYCKLKE 680 TSSFRMRHLQ 690 SLHKFVSKAT 700 AELIWLNGKE 710 EEELACDWSD 720 SNPNISAKKA 730 YFSELTMELE 740 GKQDVFRSLQ 750 DTAELLSLEN 760 HPAKQTVEAY 770 SAAVQSQLQW 780 MKQLCLCVEQ 790 HIKENAAYFQ 800 FFSDARDLES 810 FLRNLQDSIK 820 RKYTCDHNTS 830 LSRLEDLLQD 840 SMDEKEQLIQ 850 SKSSVASLVG 860 RSKTIVQLKP 870 RNPDHVLKST 880 LSVKAICDYR 890 QIEITICKND 900 ECVLEDNSQR 910 TKWKVISPTG 920 NEAMVPSVCL 930 LIPPPNTEAI 940 DVASRVEQSY 950 QKVMALWHQL 960 HINTKSLISW 970 NYLRKDIDAV 980 QTWNLEKLRS 990 SAPGECHQVM 1000 KNLQAHYEDF 1010 LQDSHDSALF 1020 SVADRLRIEE 1030 EVEACKTHFQ 1040 QLMESMENED 1050 KEETLAKVYI 1060 SELKNIRLRL 1070 EECEQRLLKQ 1080 IQSSASSKTD 1090 RDARQDVALR 1100 IAEQEHVQED 1110 LKHLRSDLDA 1120 VSVKCTTFLQ 1130 QSPSGSSATT 1140 LRSELNLMVE 1150 KMDHVYGLSI 1160 VCLNKLKTID 1170 VIVRSIQDAE 1180 LLVKGYEIKL 1190 SQEEAVPADL 1200 SALESHRTTL 1210 QHWLSDVKDK 1220 NSVFSVLDEE 1230 ISKAKAVAEQ 1240 LHHRAAEPNL 1250 DLERYQEKGS 1260 QLQERWHRVI 1270 AQLETRQSEV 1280 ESIQEVLRDY 1290 RACHGTLIKW 1300 IEETTAQQEM 1310 MKPGQAEDSR 1320 VLSEQLSQQT 1330 ELFAEIERNQ 1340 TKLDQCQKLS 1350 QQYSTTVKDY 1360 ELQLMTYKAF 1370 VESQQKSPGK 1380 RRRMISSSDA 1390 ITQEFMDLRT 1400 RYTALVTLTT 1410 QHVKYISDAL 1420 RRLEEEEKVV 1430 EEEKQEHVEK 1440 VKDLLGWVST 1450 LARNTQGTTT 1460 SSRTSASTDI 1470 EKAILEQQVL 1480 AEELTTKKEQ 1490 VSEAIKTSQI 1500 FLAKHGHKLS 1510 EREKEQISEQ 1520 LCALNKTYHD 1530 LCDGSANQLQ 1540 QLQSELAQQT 1550 EQKTLQKQQD 1560 TCHKKLEDLR 1570 SWVRQAERAL 1580 ERHRGRASQQ 1590 ELSALQQNQS 1600 DLKDLQGDIQ 1610 NHSTSFATAV 1620 KDIEGFLEEN 1630 QNKLSPQELT 1640 ALREKLYQAK 1650 EQYEGLQDRT 1660 REAQKELEEA 1670 VTSALQQETE 1680 KSKAATELAE 1690 NRRKIDALLD 1700 WVTSVGSSDR 1710 QPQTSLPGTE 1720 QFSGACLEKQ 1730 TLDATDGCVD 1740 VNQVPEKLDR 1750 QYELMKARHQ 1760 ELLSQQQNFI 1770 VATQSAQSFL 1780 DQHSHNLTPE 1790 ERQMLQEKLG 1800 ELKEQYAASL 1810 AQSEAKLRQT 1820 QTLRDELQKF 1830 LQDHREFENW 1840 LERSENELDG 1850 MHTGGSSPEA 1860 LNSLLKRQGS 1870 FSEDVISHKG 1880 DLRFVTISGQ 1890 KVLETENNFE 1900 EGQEPSPTRN 1910 LVNEKLKDAT 1920 ERYTTLHSKC 1930 TRLGSHLNML 1940 LGQYQQFQSS 1950 ADSLQAWMLT 1960 CEASVEKLLS 1970 DTVASDPGIL 1980 QQQLATTKQL 1990 QEELAEHQVP 2000 VEKLQKAAHD 2010 LMDIEGEPSL 2020 DCTPIRETTE 2030 SIFSRFQSLS 2040 CSLAERSALL 2050 QKAIAQSQSV 2060 QESMESLLQS 2070 MKEVEQNLEG 2080 EQVAALSSGL 2090 IQEALANNMK 2100 LKQDIARQKS 2110 SLEATREMVT 2120 RFMETADGNS 2130 AAVLQDRLAE 2140 LSQRFHRLQL 2150 QQQEKESGLK 2160 KLLPQAETFE 2170 QLSSKLQQFV 2180 EHKNRLLASG 2190 NQPDQDIAHF 2200 SQHIQELTLE 2210 MEDQKENLGT 2220 LEHLVTALGS 2230 CGFALDLSQH 2240 QEKIQNLKKD 2250 FTELQKTVQE 2260 REKDASNCQE 2270 QLDEFRKLIR 2280 TFQKWLKETE 2290 GNVPPAETFV 2300 SAKELEKQIE 2310 HLKGLLDDWA 2320 GKGVLVEEIN 2330 TKGTALESLI 2340 MDITAPDSQA 2350 KTGSVLPSVG 2360 SSVGSVNGYH 2370 TCKDLTEIQC 2380 DMSDVNSKYD 2390 KLGDALRERQ 2400 ESLQTVLSRM 2410 EEVQKEASSV 2420 LQWLESKEEV 2430 LKGMDASLSP 2440 TKTETVKAQA 2450 ESNKAFLAEL 2460 EQNSPKIQKV 2470 KEALAGLLEA 2480 YPNSQEAENW 2490 RKMQEDLNSR 2500 WEKATEVTVA 2510 RQKQLEESAS 2520 HLACFQAAES 2530 QLRPWLMEKE 2540 LMMGVLGPLS 2550 IDPNMLNAQK 2560 QQVQFMLKEF 2570 EARRQQHEQL 2580 TEAAQGILTG 2590 PGDVSPSASQ 2600 VHKDLQSISQ 2610 KWVELTDKLN 2620 SRSTQIDQAI 2630 VKSTQYQDLL 2640 QDLSEKVKAV 2650 GQRLSGQSAI 2660 STQPDAVKQQ 2670 LEETSEIRSD 2680 LGQLDDEMKE 2690 AQTLCQELSL 2700 LIGEQYLKDE 2710 LKKRLETVAL 2720 PLQGLEDLAA 2730 DRMNRLQAAL 2740 ASTQQFQQMF 2750 DELRTWLDEK 2760 QSQQAKNCPI 2770 SAKLERLQSQ 2780 LQENEEFQKN 2790 LNQHSGSYEV 2800 IVAEGESLLL 2810 SVPPGEEKKT 2820 LQNQLVELKS 2830 HWEDLNKKTV 2840 DRQSRLKDCM 2850 QKAQKYQWHV 2860 EDLVPWIKDC 2870 KSKMSELQVT 2880 LDPVQLESSL 2890 LRSKAMLNEA 2900 EKRRSLLEIL 2910 NSAADILINS 2920 SEIDEDEIRD 2930 EKAGLNQNMD 2940 AITEELQAKT 2950 GSLEEMTQRL 2960 KEFQESFKNI 2970 EKKVEGAKHQ 2980 LEIFDALGSQ 2990 ACSNKNLEKL 3000 KAQREVLQAL 3010 DPQVDYLRDF 3020 TRGLVEDAPD 3030 GSDASPLVHQ 3040 AELAQQEFLE 3050 VKQRVNSSCL 3060 TMENKLEGIG 3070 QFHCRVREMF 3080 SQLADLDDEL 3090 DGMGAIGRDT 3100 DSLQSQIEDI 3110 RLFLNKIQAL 3120 RLDIEDSEAE 3130 CRKMLEEEGT 3140 LDLLGLKREL 3150 EALNKQCGKL 3160 TERGKARQEQ 3170 LELTLGRVED 3180 FYSKLKALND 3190 AATAAEEGEA 3200 LQWIVGTEVD 3210 VINQQLADFK 3220 MFQKEQVDPL 3230 QVKLQQVNGL 3240 GQGLIQSAGK 3250 TCDVQGLEHD 3260 MEEVNTRWNT 3270 LNKKVAQRIA 3280 QLQEALLHCG 3290 KFQDALEPLL 3300 SWLTDTEELI 3310 ANQKPPSAEY 3320 KVVKAQIQEQ 3330 KLLQRLLDDR 3340 KATVDMLQAE 3350 GGRIAQAAEL 3360 ADREKITGQL 3370 ESLECRWTEL 3380 LSKAAARQKQ 3390 LEDILVLAKQ 3400 FHETAEPISD 3410 FLSVTEKKLA 3420 NSEPVGTQTA 3430 KIHQQIIRHK 3440 ALEEEIENHA 3450 ADVQQAVKIG 3460 QSLSSLICPA 3470 EQGIMSEKLD 3480 SLQARYSEIQ 3490 DRCCRKASLL 3500 EQALFNARLF 3510 GEDEVEVLNW 3520 LAEVEDKLSA 3530 VFVKDYRQDV 3540 LQKQHADHLA 3550 LNEEIINRKK 3560 NVDQAIKNGQ 3570 ALLKQTTGEE 3580 VLLIQEKLDG 3590 IKTRYADITV 3600 TSSKALRTLE 3610 QARQLATKFH 3620 STYEELTGWL 3630 REVEEELAAS 3640 GGQSPTGEQI 3650 PQFQQRQKEL 3660 KKEVMEHRLV 3670 LDTVNEVSHA 3680 LLELVPWRAR 3690 EGLDKLVSDA 3700 NEQYKLVSDT 3710 VGQRVDEIDA 3720 AIQRSQQYEQ 3730 AADAELAWVA 3740 ETKRKLMALG 3750 PIRLEQDQTT 3760 AQLQVQKAFS 3770 IDIIRHKDSM 3780 DELFSHRGEI 3790 FSTCGEEQKA 3800 VLQEKTECLI 3810 QQYEAVSLLN 3820 SERYARLERA 3830 QVLVNQFWET 3840 YEELSPWAEE 3850 TLALIAQLPP 3860 PAVDHEQLRQ 3870 QQEEMRQLRE 3880 SIAEHKPHID 3890 KILKIGPQLK 3900 ELNPEEGKMV 3910 EEKYQKAENM 3920 YAQIKDEVRQ 3930 RALALDEAVS 3940 QSAQIAEFHD 3950 KIEPMLETLE 3960 NLSSRLRMPP 3970 LIPAEVDKIR 3980 ECISDNKSAT 3990 MELEKLQPSF 4000 EALKRRGEEL 4010 IGRSQGADKD 4020 LAAKEIQDKL 4030 DQMVFFWEDI 4040 KARSEEREIK 4050 FLDVLELAEK 4060 FWYDMAALLT 4070 TIKDTQEIVH 4080 DLESPGIDPS 4090 IIKQQVEAAE 4100 TIKEETDGLH 4110 EELEFIRILG 4120 ADLIFACGET 4130 EKPEVKKSID 4140 EMNNAWENLN 4150 RTWKERLEKL 4160 EDAMQAAVQY 4170 QDTLQAMFDW 4180 LDNTVIRLCT 4190 MPPVGTDLNT 4200 VKDQLNEMKE 4210 FKVEVYQQQI 4220 EMEKLNHQGE 4230 LMLKKATDET 4240 DRDIIREPLT 4250 ELKHLWENLG 4260 EKIAHRQHKL 4270 EGALLALGQF 4280 QHALEELMGW 4290 LTHTEELLDA 4300 QRPISGDPKV 4310 IEVELAKHHV 4320 LKNDVLAHQA 4330 TVETVNKAGN 4340 ELLESSAGDD 4350 ASSLRSRLET 4360 MNQCWESVLQ 4370 KTEEREQQLQ 4380 STLQQAQGFH 4390 SEIEEFLLEL 4400 NRMESQLSAS 4410 KPTGGLPETA 4420 REQLDAHMEL 4430 HSQLRAKEEI 4440 YNQLLDKGRL 4450 MLLSRGDSGS 4460 GSKTEQSVAL 4470 LEQKWHVVSS 4480 KVEERKSKLE 4490 EALSLATEFQ 4500 NSLQEFINWL 4510 TLAEQSLNIA 4520 SPPSLILNTV 4530 LSQIEEHKVF 4540 ANEVNAHRDQ 4550 IIELDQTGNQ 4560 LKFLSQKQDV 4570 VLIKNLLVSV 4580 QSRWEKVVQR 4590 SIERGRSLDD 4600 ARKRAKQFHE 4610 AWKKLIDWLE 4620 DAESHLDSEL 4630 EISNDPDKIK 4640 LQLSKHKEFQ 4650 KTLGGKQPVY 4660 DTTIRTGRAL 4670 KEKTLLADDA 4680 QKLDNLLGEV 4690 RDKWDTVCGK 4700 SVERQHKLEE 4710 ALLFSGQFMD 4720 ALQALVDWLY 4730 KVEPQLAEDQ 4740 PVHGDLDLVM 4750 NLMDAHKVFQ 4760 KELGKRTGTV 4770 QVLKRSGREL 4780 IESSRDDTTW 4790 VKGQLQELST 4800 RWDTVCKLSV 4810 SKQSRLEQAL 4820 KQAEEFRDTV 4830 HMLLEWLSEA 4840 EQTLRFRGAL 4850 PDDTEALQSL 4860 IDTHKEFMKK 4870 VEEKRVDVNA 4880 AVAMGEVILA 4890 VCHPDCITTI 4900 KHWITIIRAR 4910 FEEVLTWAKQ 4920 HQQRLETALS 4930 ELVANAELLE 4940 ELLAWIQWAE 4950 TTLIQRDQEP 4960 IPQNIDRVKA 4970 LITEHQSFME 4980 EMTRKQPDVD 4990 RVTKTYKRKN 5000 IEPTHAPFIE 5010 KSRSGSRKSL 5020 NQPTPPPMPI 5030 LSQSEAKNPR 5040 INQLSARWQQ 5050 VWLLALERQR 5060 KLNDALDRLE 5070 ELKEFANFDF 5080 DVWRKKYMRW 5090 MNHKKSRVMD 5100 FFRRIDKDQD 5110 GKITRQEFID 5120 GILASKFPTT 5130 KLEMTAVADI 5140 FDRDGDGYID 5150 YYEFVAALHP 5160 NKDAYRPTTD 5170 ADKIEDEVTR 5180 QVAQCKCAKR 5190 FQVEQIGENK 5200 YRFGDSQQLR 5210 LVRILRSTVM 5220 VRVGGGWMAL 5230 DEFLVKNDPC 5240 RARGRTNIEL 5250 REKFILPEGA 5260 SQGMTPFRSR 5270 GRRSKPSSRA 5280 ASPTRSSSSA 5290 SQSNHSCTSM 5300 PSSPATPASG 5310 TKVISSTGSK 5320 LKRPTPTFHS 5330 SRTSLAGDTS 5340 NSSSPASTGA 5350 KTNRADPKKS 5360 ASRPGSRAGS 5370 RAGSRASSRR 5380 GSDASDFDLL 5390 ETQSACSDTS 5400 ESSAAGGQGS 5410 SRRGLTKPSK 5420 IPTMSKKTTT 5430 ASPRTPCPKR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0032587 ruffle membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0051011 microtubule minus-end binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0016477 cell migration
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0001707 mesoderm formation
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:0030177 positive regulation of Wnt signaling pathway
Biological Process GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0010632 regulation of epithelial cell migration
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:0032886 regulation of microtubule-based process
Biological Process GO:0150011 regulation of neuron projection arborization
Biological Process GO:0016055 Wnt signaling pathway
Biological Process GO:0042060 wound healing

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.