Search Results
Overview
| Uniprot ID | D3ZI68 |
|---|---|
| Protein Name | U4/U6 small nuclear ribonucleoprotein Prp31 |
| Gene Name | Prpf31 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 417 | TQVNEATKARISKTL |
| 422 | ATKARISKTLQRTLQ |
| 430 | TLQRTLQKQSVVYGG |
| 438 | QSVVYGGKSTIRDRS |
Function
Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome
Protein Sequence
10
MSLADELLAD
20
LEEAAEEEEG
30
GSYGEEEEEP
40
AIEDVQEETQ
50
LDLSGDSVKS
60
IAKLWDSKMF
70
AEIMMKIEEY
80
ISKQAKASEV
90
MGPVEAAPEY
100
RVIVDANNLT
110
VEIENELNII
120
HKFIRDKYSK
130
RFPELESLVP
140
NALDYIRTVK
150
ELGNSLDKCK
160
NNENLQQILT
170
NATIMVVSVT
180
ASTTQGQQLS
190
DEELERLEEA
200
CDMALELNAS
210
KHRIYEYVES
220
RMSFIAPNLS
230
IIIGASTAAK
240
IMGVAGGLTN
250
LSKMPACNIM
260
LLGAQRKTLS
270
GFSSTSVLPH
280
TGYIYHSDIV
290
QSLPPDLRRK
300
AARLVAAKCT
310
LAARVDSFHE
320
STEGKVGYEL
330
KDEIERKFDK
340
WQEPPPVKQV
350
KPLPAPLDGQ
360
RKKRGGRRYR
370
KMKERLGLTE
380
IRKQANRMSF
390
GEIEEDAYQE
400
DLGFSLGHLG
410
KSGSGRVRQT
420
QVNEATKARI
430
SKTLQRTLQK
440
QSVVYGGKST
450
IRDRSSGTAS
460
SVAFTPLQGL
470
EIVNPQAAEK
480
KVAEANQKYF
490
SSMAEFLKVK
GEKSGTMST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0071339 | MLL1 complex |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071016 | U12-type precatalytic spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0005687 | U4 snRNP |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005690 | U4atac snRNP |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0070990 | snRNP binding |
| Molecular Function | GO:0030621 | U4 snRNA binding |
| Molecular Function | GO:0030622 | U4atac snRNA binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0071166 | ribonucleoprotein complex localization |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.