Search Results
Overview
| Uniprot ID | D3ZI99 |
|---|---|
| Protein Name | U4/U6 small nuclear ribonucleoprotein Prp3 |
| Gene Name | Prpf3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | GDDSEISKESSGVKK |
| 282 | THRMPTLKANIRAVK |
| 294 | AVKREQFKQQLKEKP |
| 328 | QRQRRTFKFHDKGKF |
| 337 | HDKGKFEKIAQRLRT |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)
Protein Sequence
10
MALSKRELDE
20
LKPWIEKTVK
30
RVLGFSEPTV
40
VTAALNCVGK
50
GMDKKKAADH
60
LKPFLDDSTL
70
RFVDKLFEAV
80
EEGRSSRHSK
90
SSSDRSRKRE
100
LKEVFGDDSE
110
ISKESSGVKK
120
RRIPRFEEVE
130
EEPEVIPGPP
140
SESPGMLTKL
150
QIKQMMEAAT
160
RQIEERKKQL
170
SFISPPAPQP
180
KTPSSSQPER
190
LPIGNTIQPS
200
QAATFMNDAI
210
EKARKAAELQ
220
ARIQAQLALK
230
PGLIGNANMV
240
GLANLHAMGI
250
APPKVELKDQ
260
TKPTPLILDE
270
QGRTVDATGK
280
EVELTHRMPT
290
LKANIRAVKR
300
EQFKQQLKEK
310
PSEDMESNTF
320
FDPRVSIAPS
330
QRQRRTFKFH
340
DKGKFEKIAQ
350
RLRTKAQLEK
360
LQAEISQAAR
370
KTGIHTSTRL
380
ALIAPKKELK
390
EGDIPEIEWW
400
DSYIIPNGFD
410
LTEENPKRED
420
YFGITNLVEH
430
PAQLNPPVDN
440
DTPVTLGVYL
450
TKKEQKKLRR
460
QTRREAQKEL
470
QEKVRLGLTP
480
PPEPKVRISN
490
LMRVLGTEAV
500
QDPTKVEAHV
510
RAQMAKRQKA
520
HEEANAARKL
530
TAEQRKVKKV
540
KKLKEDISQG
550
VHISVYRVRN
560
LSNPAKKFKI
570
EANAGQLYLT
580
GVVVLHKDVN
590
VVVVEGGPKA
600
QKKFKRLMLH
610
RIKWDEQTSN
620
TKGDGHSQRP
630
ELWRDEVQTV
PYREHGA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.