Overview
| Uniprot ID | D3ZIU9 |
|---|
| Protein Name | HMG box domain-containing protein |
|---|
| Gene Name | LOC134485624 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 82 |
MKTYIPPKGETKKKF |
| 90 |
GETKKKFKDPNAPKR |
Function
In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages
Protein Sequence
10
MGKGDPKKPR
20
GKMSSYAFFV
30
QTCREEHKKK
40
HPDASVNFSE
50
VSKKCSERWK
60
TMSAKEKGKF
70
EDMAKADKAR
80
YEREMKTYIP
90
PKGETKKKFK
100
DPNAPKRPPS
110
AFFLFCSEYR
120
PKIKGEHPGL
130
SIGDVAKKLG
140
EMWNNTASDD
150
KQPYEKKAAK
160
LKEKYEKDTA
170
AYRAKGKPDA
180
AKKGVVKAEK
190
SKKKKEEEDD
200
EEDEEDEEEE
210
EEEEDEDEEE
DDDE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.