Search Results

Overview

Uniprot IDD3ZJH9
Protein NameMalic enzyme
Gene NameMe2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
26 VHLKEKGKPLMLNPR

Function

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate

Protein Sequence

10 MFSRLRAVTT 20 PCTLTCRRVH 30 LKEKGKPLML 40 NPRTNKGMAF 50 TLQERQMLGL 60 QGLLPPKIET 70 QDIQALRFHR 80 NLKKMTSPLE 90 KYIYIMGIQE 100 RNEKLFYRIL 110 QDDIESLMPI 120 VYTPTVGLAC 130 CQYGHIFRRP 140 KGLFISISDR 150 GHVRSIVDNW 160 PENHVKAVVV 170 TDGERILGLG 180 DLGVYGMGIP 190 VGKLCLYTAC 200 AGIQPEKCLP 210 VCIDVGTDNM 220 ALLKDPFYMG 230 LYQKRDRSQL 240 YDDLMDEFMK 250 AITDRYGRNT 260 LIQFEDFGNH 270 NAFRFLKKYQ 280 EKYCTFNDDI 290 QGTAAVALSG 300 LLAAQRVINK 310 PISEHRILFL 320 GAGEAALGIA 330 KLIVISMMES 340 GLSEEEAQRK 350 IWMFDKNGLL 360 VKGRTARIDS 370 NQEPYAHAAS 380 ENIPATFEDA 390 VNKLKPSVII 400 GVAGAGPLFT 410 PGVIKAMAAI 420 NERPIIFALS 430 NPTAQAECTA 440 EDAYTLTEGR 450 CLFASGSPFE 460 PVRLQDGRVF 470 TPGQGNNAYI 480 FPGVALAVIL 490 CEARHISDTV 500 FLEAAKALTS 510 QLTDEELAQG 520 RLYPSLANIQ 530 EVSANIAIKI 540 AEYLYANKMA 550 FRYPEPEDKA 560 KYVKERIWRS 570 NYVSLLPDVY 580 DWPESSLKPP QIPE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
Molecular Function GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
Molecular Function GO:0004470 malic enzyme activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006108 malate metabolic process
Biological Process GO:1902031 regulation of NADP metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.