Search Results
Overview
| Uniprot ID | D3ZJK3 |
|---|---|
| Protein Name | Histone deacetylase complex subunit SAP30L |
| Gene Name | Sap30l |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 179 | DQKPEGSKQLE**** |
Function
Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import
Protein Sequence
10
MNGFSTEEDS
20
REGPPAAPAA
30
APGYGQSCCL
40
IADGERCVRP
50
AGNASFSKRV
60
QKSISQKKLK
70
LDIDKSVRHL
80
YICDFHKNFI
90
QSVRNKRKRK
100
TSDDGGDSPE
110
HDADIPEVDL
120
FQLQVNTLRR
130
YKRHYKLQTR
140
PGFNKAQLAE
150
TVSRHFRNIP
160
VNEKETLAYF
170
IYMVKSNRSR
180
LDQKPEGSKQ
LE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0044378 | non-sequence-specific DNA binding, bending |
| Molecular Function | GO:0031491 | nucleosome binding |
| Molecular Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Molecular Function | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| Molecular Function | GO:0010314 | phosphatidylinositol-5-phosphate binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.