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Overview

Uniprot ID	D3ZJR1
Protein Name	Epidermal growth factor receptor substrate 15-like 1
Gene Name	Eps15l1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
400	IAQLQREKYSLEQDI
546	DINQARSKLSQLQES

Function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Protein Sequence

10 MAAPLLPLSQ 20 QIPSGNPLYE 30 SYYKQVDPAY 40 TGRVGASEAA 50 LFLKKSGLSD 60 IVLGKIWDLA 70 DPEGKGFLDK 80 QGFYVALRLV 90 ACAQSGHEVT 100 LSNLGLTMPP 110 PKFHDTSSPL 120 MATQSSAEAH 130 WAVRVEEKAK 140 FDGIFESLLP 150 VNGLLSGDKV 160 KPVLMNSKLP 170 LDVLGRVWDL 180 SDIDKDGHLD 190 RDEFAVAMHL 200 VYRALEKEPV 210 PSVLPPPLIP 220 PSKRKKTVFA 230 GAVPVLPASP 240 PPKDSLRSTP 250 SHGSVSSLNS 260 TGSLSPKHSV 270 KQTQPPVAWV 280 VPVADKMRFD 290 EIFLKTDLDL 300 DGYVSGQEVK 310 EIFMHSGLTQ 320 NLLAHIWALA 330 DTRQTGKLSK 340 EQFALAMYFI 350 QQKVSKGIDP 360 PQVLSPDMVP 370 PSERGTPIPD 380 SSSALGSGEF 390 TGVKELDDIS 400 QEIAQLQREK 410 YSLEQDIREK 420 EEAIRQKASE 430 VQELQNDLDR 440 ETSSLQELEA 450 QKQDAQDRLD 460 EMDQQKAKLR 470 DMLSDVRQKC 480 QDETQTISSL 490 KTQIQSQESD 500 LKSQEDDLNR 510 AKSELNRLQQ 520 EETQLEQSIQ 530 AGRAQLETIL 540 RSLKCTQDDI 550 NQARSKLSQL 560 QESHLEAHRS 570 LEQYDQVPDG 580 VSGTSLPDLA 590 TLNEGILLAE 600 RGGFGAMVKD 610 DPFKNKALLF 620 SNNSQELHPD 630 PFQAEDPFKS 640 DPFKGADPFK 650 GDPFQSDPFS 660 EQQTAVTDPF 670 GGDPFKESDP 680 FHSSTSDDFF 690 KKQTKNDPFT 700 SDPFTKNPSL 710 PSKLDPFESS 720 DPFSSSSISS 730 KGSDPFGTLD 740 PFGSSSFSSA 750 EGFADFSQMS 760 KPPPSGPFSS 770 SLGGTGFSDD 780 PFKSKQDTPA 790 LPPKKPAPPR 800 PKPPSGQSTP 810 VSQLGSSAFP 820 ESPDPFQPLE 830 ADSGDPFQNK 840 KGFGDPFSGK 850 DPFAPSSSAK 860 PPKASSSGFA 870 DFTSFGNEEQ 880 QLAWAKRESE 890 KAEQERLARL 900 RRQEQEDLEL 910 AIALSKADMP A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030132	clathrin coat of coated pit
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098793	presynapse
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0016197	endosomal transport
Biological Process	GO:0048488	synaptic vesicle endocytosis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.