Search Results
Overview
| Uniprot ID | D3ZK47 |
|---|---|
| Protein Name | Histone-lysine N-methyltransferase NSD3 |
| Gene Name | Nsd3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 478 | WRTAAARKSLPASIT |
Function
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression
Protein Sequence
10
MASRIMGNTI
20
QQPPQLIDSA
30
NIRQEDAFDN
40
NSDIVEDGGP
50
TPFEATLQQG
60
FQCPPATEDL
70
PPLTNGYPPS
80
ISLYETQTKY
90
PPYSQYPNGS
100
ANGFGAVRNF
110
SPTDYYHSEI
120
PNTRPHEILE
130
KPSPPQPPPP
140
PLLPPPPPPV
150
PQTVIPKKTG
160
SPEIKLKITK
170
TIQNGRELFE
180
SSLCGDLLNE
190
VQASEHLKSK
200
HESRKEKRKK
210
SSRHESSRSE
220
ERKSHKVPKL
230
EPEGQNRPNE
240
RVDPAPEKPR
250
EEPVLKEAVP
260
VQPILSSVPT
270
TETSTGVKFQ
280
VGDLVWSKVG
290
TYPWWPCMVS
300
SDPQLEVHTK
310
INTRGAREYH
320
VQFFSNQPER
330
AWVHEKRVRE
340
YKGHEQYEEL
350
LAEAAKQASN
360
HSEKQKIRKP
370
RPQRERAQWD
380
IGIAHAEKAL
390
QMTREERVEQ
400
YTFIYIDKQP
410
EESPSQAKKS
420
VTSKAEVKKP
430
RRPRSVGNSQ
440
PEQTSAGEVA
450
SPQSSTDPRR
460
QSQRRHTSVE
470
EDGPPPVKIA
480
WRTAAARKSL
490
PASITMHKGS
500
LDLHKCNMSP
510
VVKIEQVFAL
520
QNATGDGKFI
530
DQFVYSTKGI
540
GNKTEISVRG
550
QDRLIISSPS
560
QRNEKSTPSA
570
SPPEATSGSA
580
GPVEKKQQRR
590
SIRTRSESEK
600
STEVVSKKKI
610
KKEQVETSPQ
620
ASLKTGLQKG
630
ASEISDSCKP
640
LKKRSRASTD
650
VETASCTYRD
660
TSDSDSRGPS
670
DGQVGFGKQV
680
DSPSAAADAD
690
ASDAQSVDSS
700
LSRRGVGLSK
710
KDTVCQVCEN
720
TGDSLVACEG
730
ECCRHFHPEC
740
LGLAAVPEGR
750
FTCEECETGQ
760
HPCFSCKVSG
770
KDVKRCSVSV
780
CGKFYHEACV
790
RKFPTAIFES
800
KGFRCPQHCC
810
SSCSMEKDIH
820
KASKGRMMKC
830
LRCPIAYHFG
840
DACVAAGSVS
850
VSSHILICSN
860
HSKRSSHSAA
870
INVGFCFVCA
880
RGGRLLCCES
890
CPASFHPECL
900
SIDMPEGCWN
910
CNDCKAGKKL
920
HYKQIVWVKL
930
GNYRQVSQAD
940
RKWWPAETCS
950
PRSVPLNIQG
960
LKHGVGDFPV
970
LFFGSHDYYW
980
VHQGRVFPYV
990
EGDTNFAEGQ
1000
TSINKTFKKA
1010
LEEAAKRFQE
1020
LKAQRESKEA
1030
LEIEKTSRKP
1040
PPYKHIKANK
1050
VIGKVQIQVA
1060
DLSEIPRCNC
1070
KPGDENPCGL
1080
ESECLNRMSQ
1090
YECHPQVCPA
1100
GDRCQNQCFT
1110
KRLYPDAEII
1120
KTERRGWGLR
1130
TKRSIKKGEF
1140
VNEYVGELID
1150
EEECRLRIKR
1160
AHENSVTNFY
1170
MLTVTKDRII
1180
DAGPKGNYSR
1190
FMNHSCNPNC
1200
ETQKWTVNGD
1210
VRVGLFALCD
1220
IPAGMELTFN
1230
YNLDCLGNGR
1240
TVCHCGADNC
1250
SGFLGVRPKS
1260
ACTSAADEKT
1270
KNAKLKKRRR
1280
GKAEAKQIHE
1290
DYCFQCGDGG
1300
ELVMCDKKDC
1310
PKAYHLLCLN
1320
LTQPPYGKWE
1330
CPWHQCDECG
1340
SAAISFCEFC
1350
PHSFCKAHEK
1360
GALVPSALEG
1370
RLCCSNHDPA
1380
SPVSPEYWSK
1390
MRCKWESQDG
GEEVKE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0140952 | histone H3K27 dimethyltransferase activity |
| Molecular Function | GO:0140946 | histone H3K4 dimethyltransferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.