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Overview

Uniprot IDD3ZK47
Protein NameHistone-lysine N-methyltransferase NSD3
Gene NameNsd3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
478 WRTAAARKSLPASIT

Function

Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression

Protein Sequence

10 MASRIMGNTI 20 QQPPQLIDSA 30 NIRQEDAFDN 40 NSDIVEDGGP 50 TPFEATLQQG 60 FQCPPATEDL 70 PPLTNGYPPS 80 ISLYETQTKY 90 PPYSQYPNGS 100 ANGFGAVRNF 110 SPTDYYHSEI 120 PNTRPHEILE 130 KPSPPQPPPP 140 PLLPPPPPPV 150 PQTVIPKKTG 160 SPEIKLKITK 170 TIQNGRELFE 180 SSLCGDLLNE 190 VQASEHLKSK 200 HESRKEKRKK 210 SSRHESSRSE 220 ERKSHKVPKL 230 EPEGQNRPNE 240 RVDPAPEKPR 250 EEPVLKEAVP 260 VQPILSSVPT 270 TETSTGVKFQ 280 VGDLVWSKVG 290 TYPWWPCMVS 300 SDPQLEVHTK 310 INTRGAREYH 320 VQFFSNQPER 330 AWVHEKRVRE 340 YKGHEQYEEL 350 LAEAAKQASN 360 HSEKQKIRKP 370 RPQRERAQWD 380 IGIAHAEKAL 390 QMTREERVEQ 400 YTFIYIDKQP 410 EESPSQAKKS 420 VTSKAEVKKP 430 RRPRSVGNSQ 440 PEQTSAGEVA 450 SPQSSTDPRR 460 QSQRRHTSVE 470 EDGPPPVKIA 480 WRTAAARKSL 490 PASITMHKGS 500 LDLHKCNMSP 510 VVKIEQVFAL 520 QNATGDGKFI 530 DQFVYSTKGI 540 GNKTEISVRG 550 QDRLIISSPS 560 QRNEKSTPSA 570 SPPEATSGSA 580 GPVEKKQQRR 590 SIRTRSESEK 600 STEVVSKKKI 610 KKEQVETSPQ 620 ASLKTGLQKG 630 ASEISDSCKP 640 LKKRSRASTD 650 VETASCTYRD 660 TSDSDSRGPS 670 DGQVGFGKQV 680 DSPSAAADAD 690 ASDAQSVDSS 700 LSRRGVGLSK 710 KDTVCQVCEN 720 TGDSLVACEG 730 ECCRHFHPEC 740 LGLAAVPEGR 750 FTCEECETGQ 760 HPCFSCKVSG 770 KDVKRCSVSV 780 CGKFYHEACV 790 RKFPTAIFES 800 KGFRCPQHCC 810 SSCSMEKDIH 820 KASKGRMMKC 830 LRCPIAYHFG 840 DACVAAGSVS 850 VSSHILICSN 860 HSKRSSHSAA 870 INVGFCFVCA 880 RGGRLLCCES 890 CPASFHPECL 900 SIDMPEGCWN 910 CNDCKAGKKL 920 HYKQIVWVKL 930 GNYRQVSQAD 940 RKWWPAETCS 950 PRSVPLNIQG 960 LKHGVGDFPV 970 LFFGSHDYYW 980 VHQGRVFPYV 990 EGDTNFAEGQ 1000 TSINKTFKKA 1010 LEEAAKRFQE 1020 LKAQRESKEA 1030 LEIEKTSRKP 1040 PPYKHIKANK 1050 VIGKVQIQVA 1060 DLSEIPRCNC 1070 KPGDENPCGL 1080 ESECLNRMSQ 1090 YECHPQVCPA 1100 GDRCQNQCFT 1110 KRLYPDAEII 1120 KTERRGWGLR 1130 TKRSIKKGEF 1140 VNEYVGELID 1150 EEECRLRIKR 1160 AHENSVTNFY 1170 MLTVTKDRII 1180 DAGPKGNYSR 1190 FMNHSCNPNC 1200 ETQKWTVNGD 1210 VRVGLFALCD 1220 IPAGMELTFN 1230 YNLDCLGNGR 1240 TVCHCGADNC 1250 SGFLGVRPKS 1260 ACTSAADEKT 1270 KNAKLKKRRR 1280 GKAEAKQIHE 1290 DYCFQCGDGG 1300 ELVMCDKKDC 1310 PKAYHLLCLN 1320 LTQPPYGKWE 1330 CPWHQCDECG 1340 SAAISFCEFC 1350 PHSFCKAHEK 1360 GALVPSALEG 1370 RLCCSNHDPA 1380 SPVSPEYWSK 1390 MRCKWESQDG GEEVKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140952 histone H3K27 dimethyltransferase activity
Molecular Function GO:0140946 histone H3K4 dimethyltransferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032259 methylation
Biological Process GO:0045892 negative regulation of DNA-templated transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.