Search Results

Overview

Uniprot ID	D3ZK96
Protein Name	Poly(A) polymerase
Gene Name	Papola
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
635	PSGNAATKVPNPIVG
644	PNPIVGVKRTSSPHK

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's

Protein Sequence

10 MPFPVTTQGS 20 QQTQPPQRHY 30 GITSPISLAA 40 PKETDCLLTQ 50 KLIETLKPFG 60 VFEEEEELQR 70 RILILGKLNN 80 LVKEWIREIS 90 ESKNLPQSVI 100 ENVGGKIFTF 110 GSYRLGVHTK 120 GADIDALCVA 130 PRHVDRSDFF 140 TSFYDKLKLQ 150 EEVKDLRAVE 160 EAFVPVIKLC 170 FDGIEIDILF 180 ARLALQTIPE 190 DLDLRDDSLL 200 KNLDIRCIRS 210 LNGCRVTDEI 220 LHLVPNIDNF 230 RLTLRAIKLW 240 AKRHNIYSNI 250 LGFLGGVSWA 260 MLVARTCQLY 270 PNAIASTLVH 280 KFFLVFSKWE 290 WPNPVLLKQP 300 EECNLNLPVW 310 DPRVNPSDRY 320 HLMPIITPAY 330 PQQNSTYNVS 340 VSTRMVMVEE 350 FKQGLAITDE 360 ILLSKAEWSK 370 LFEAPNFFQK 380 YKHYIVLLAS 390 APTEKQRLEW 400 VGLVESKIRI 410 LVGSLEKNEF 420 ITLAHVNPQS 430 FPAPKESPDR 440 EEFRTMWVIG 450 LVFKKTENSE 460 NLSVDLTYDI 470 QSFTDTVYRQ 480 AINSKMFELD 490 MKIAAMHVKR 500 KQLHQLLPSH 510 VLQKRKKHST 520 EGVKLAALND 530 SSLDLSMDSD 540 NSMSVPSPTS 550 AMKTSPLNSS 560 GSSQGRNSPA 570 PAVTAASVTS 580 IQASEVSVPQ 590 ANSSESPGGP 600 SSESIPQTAT 610 QPAISPPPKP 620 TVSRVVSSTR 630 LVNPSPRPSG 640 NAATKVPNPI 650 VGVKRTSSPH 660 KEESPKKTKT 670 EEEQVGMETS 680 AAPSEAAPAS 690 ASLVASQKTS 700 STDLSDIPAL 710 PANPIPVIKN SIKLRLNR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:1990817	poly(A) RNA polymerase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0031123	RNA 3'-end processing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.