Search Results
Overview
| Uniprot ID | D3ZKG1 |
|---|---|
| Protein Name | Methylmalonyl-CoA mutase, mitochondrial |
| Gene Name | Mmut |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 685 | KEITSAIKRVNKFME |
Function
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle
Protein Sequence
10
MKKPDTLVEK
20
GWTKGVCLIR
30
HQTRARNGGI
40
GLAEPRAELA
50
TPPELTGSGA
60
PAASASGSRA
70
LGFDLRGRPP
80
TLFVLIFVWE
90
YSCFTMLRAK
100
NQLFLLSPHY
110
LKQLKDASSY
120
RWKRLLHQQQ
130
PLHPEWAVLA
140
KKQLKGKNPE
150
DLIWHTPEGI
160
SIKPLYSRAD
170
TMDLPEELPG
180
VKPFTRGPYP
190
TMYTYRPWTI
200
RQYAGFSTVE
210
ESNKFYKDNI
220
KAGQQGLSVA
230
FDLATHRGYD
240
SDNPRVRGDV
250
GMAGVAIDTV
260
EDTKILFDGI
270
PLEKMSVSMT
280
MNGAVIPVLA
290
TFIVTGEEQG
300
VPKEKLTGTI
310
QNDILKEFMV
320
RNTYIFPPEP
330
SMKIIADIFQ
340
YTAQHMPKFN
350
SISISGYHMQ
360
EAGADAILEL
370
AYTIADGLEY
380
CRTGLQAGLT
390
IDEFAPRLSF
400
FWGIGMNFYM
410
EIAKMRAGRR
420
LWAHLIEKMF
430
QPKNSKSLLL
440
RAHCQTSGWS
450
LTEQDPYNNI
460
VRTAIEAMAA
470
VFGGTQSLHT
480
NSFDEALGLP
490
TVKSARIARN
500
TQIIIQEESG
510
IPKVADPWGG
520
SYMMESLTND
530
VYEAALKLIY
540
EVEEMGGMAK
550
AVAEGIPKLR
560
IEECAARRQA
570
RIDSGSEVIV
580
GVNKYQLEKE
590
DSVEVLAIDN
600
TSVRKKQIEK
610
LKKIKSSRDQ
620
ALAERSLNAL
630
TQCAASGDGN
640
ILALAVDAAR
650
ARCTVGEITD
660
ALKKVFGEHK
670
ANDRMVSGAY
680
RQEFGESKEI
690
TSAIKRVNKF
700
MEREGRRPRL
710
LVAKMGQDGH
720
DRGAKVIATG
730
FADLGFDVDI
740
GPLFQTPREV
750
AQQAVDADVH
760
AVGVSTLAAG
770
HKTLVPELIK
780
ELSALGRPDI
790
LVMCGGVIPP
800
QDYEFLYEVG
810
VSNVFGPGTR
820
IPKAAVQVLD
830
DIEKSLAEKQ
QSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0031419 | cobalamin binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004494 | methylmalonyl-CoA mutase activity |
| Molecular Function | GO:0072341 | modified amino acid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0050667 | homocysteine metabolic process |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0019678 | propionate metabolic process, methylmalonyl pathway |
| Biological Process | GO:1901290 | succinyl-CoA biosynthetic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.