Search Results

Overview

Uniprot IDD3ZKV7
Protein NameTrinucleotide repeat-containing gene 18 protein
Gene NameTnrc18
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1975 RKDTGRAKDRKDPRK
1978 TGRAKDRKDPRKKKR

Function

Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12. Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing

Protein Sequence

10 MDGRDFGPQR 20 SVHGPPPPLL 30 SGLAMDSHRV 40 GAATAGRLPS 50 SGLPGPPPPG 60 KYMAGLNLHP 70 HPGFSHLPSG 80 LYPSYLHLNH 90 LEPPSSGSPL 100 LSQLGQPSIF 110 DTQKDGFYLP 120 APGTLHAHTP 130 SSRTPSGHSS 140 GGTAKGSSRE 150 GTGKDRSSRG 160 GDPPPLFGKK 170 DPRAREEVSG 180 PRGVVDLTQE 190 VRAEGRQDRG 200 SSRLAERLSP 210 FLAEAKAKGA 220 LQPSALSLCN 230 GVVDAGLVAE 240 LSRGGAKEVA 250 RQEENARLLR 260 RAEALLPAAR 270 PCGSPLPPPP 280 PPLPPKGPPA 290 PPSSTPAGVY 300 TVFREPGREH 310 RVVAPTFVPS 320 VEAFDERVGP 330 IQIASQARDV 340 RAREREPGRP 350 GVLQGPPGSP 360 RLERPEVLRE 370 KSSVIRSLKR 380 PPPSDGPPAA 390 RSSRSSPDAR 400 AYLPPKELLK 410 PEADPRPCER 420 APRGPSSSAA 430 QQAAKLFGLE 440 PSRPPGPEHK 450 WKPFELGNFA 460 TTQMAVLAAQ 470 HHHASRAEEE 480 AAVATASKKA 490 YLDPGGAMPR 500 ASATCGRPGA 510 DLHSAAAHGP 520 GEASAMQSLI 530 KYSGSFAREA 540 VAVRPGGCGK 550 KSPFGGLGTM 560 KPEPIPTSAG 570 PPRAQARLTH 580 PGVPTAGGGR 590 QLKRDPERPE 600 SAKTFGREGS 610 GAQGEAEVRH 620 PPVGIAVAVA 630 RQKDSGSSSR 640 LGPGLIDQER 650 SLSLNNVKGH 660 GRTEDDCDRA 670 RHREDRLLGT 680 RLDRDQEKLL 690 RESKELADLA 700 RLHPTSCAPN 710 GLNPNLMVTG 720 GPTLAGSGRW 730 SADPAAHLAT 740 HPWLPRSGST 750 SMWLAGHPYG 760 LGPPSLHQGM 770 APAFPPGLGG 780 SLPSAYQFVR 790 DPQSGQLVVI 800 PSDHLPHFAE 810 LMERATVPPL 820 WPALYPPGRS 830 PLHHAQQLQL 840 FSQQHFLRQQ 850 ELLYLQQQAA 860 QALELQRSAQ 870 LVQERLKAQE 880 HRTEMEEKIT 890 KRGLETTGKA 900 GLSATGPGLL 910 PQKSAGLATG 920 PTGTHGKAMS 930 PPPSPRASPV 940 TSLKAKVIQK 950 VEDVSKPPAY 960 TYPATPSSHP 970 SSPPPASPPP 980 TPGLTRKEEA 990 PENVVEKKDL 1000 ELEKEAPSPF 1010 QALFTDIPPR 1020 YPFQALPPHY 1030 GRPYPFLLQP 1040 TAAADADGLA 1050 PDVPLPADGP 1060 ERLALSPEDK 1070 PICLSPSKIP 1080 EPPRDSQEEE 1090 RLADREVKAE 1100 IEDIEEGPTE 1110 LPRLESPLAL 1120 PVPETMVAVS 1130 PAGGCGGSPL 1140 EAQALSTAGP 1150 GCREPSEVSD 1160 FAQVAEPQIE 1170 LPSRTEPHMA 1180 ALELGTQLTP 1190 EPLVEAKEEP 1200 VEVPLDVPME 1210 EPVAETGPED 1220 SLPQPPLTEP 1230 PPSLELSDCD 1240 LPVPEGQCLN 1250 LEAQEAAPAP 1260 ASTYLEETHP 1270 ESLLPGLDDP 1280 LAGMNALAAA 1290 AELPQARPLP 1300 SLGTGVPGGE 1310 KLDTAPSLVL 1320 EHSFLQGITL 1330 LSEIAELELD 1340 RRGQEVPGPE 1350 PNLVVRPSLE 1360 SLLAASSHML 1370 KEVLESPLSD 1380 SLKNLRLPRE 1390 LNSNKKYSWM 1400 QKKEERMFAM 1410 KSSLEDMDAL 1420 ELDFRMRLAE 1430 VQRRYKEKQR 1440 ELVKLQRRRD 1450 SGDRHEDAHR 1460 SLTRRGPGRP 1470 RKRTHTPSAL 1480 SPPCKRGKSH 1490 SGSGKLSSKS 1500 LLTSDDYDLG 1510 AGIRKRHKGP 1520 EEEQEALVSM 1530 GKARSRNQSW 1540 DDHESSSDFM 1550 SQLKIKKKKM 1560 SSDQEQLASK 1570 LDRALSLTKQ 1580 DKLKSPFKFS 1590 DSPGGKWKTS 1600 GGCGRFLTQC 1610 DSLLGKDRKA 1620 LAKGLGLSLK 1630 PSREGKHKRA 1640 SKARKMEGGF 1650 KARGQPKSVH 1660 SPFASEVSSH 1670 SYNTDSDEDE 1680 DLLKNSWSAQ 1690 GPSSSKLTSS 1700 LLGMVAKNSK 1710 PATGPKLTKR 1720 GPSGPRTLKP 1730 KEATSRKQSF 1740 CLLLREAEAH 1750 SSFSDSSAED 1760 SFDQDDSSEE 1770 EEEELEEEEE 1780 DEEEEGIGSY 1790 RLGAGEQALS 1800 PSLEESGLGL 1810 LARFAASALP 1820 SPVVGPPLSV 1830 VQLEAEQKAR 1840 KKEERQSLMG 1850 TEFEYTDSES 1860 EVKVPKQSPA 1870 GLLRPKKGAG 1880 EPGQSLAAPV 1890 PGTRASGPTS 1900 PDKAKLASEK 1910 GRKARKIRGS 1920 KEPGFEAGPE 1930 ASDDDLWTRR 1940 RSERIFLHDA 1950 SAAVQAPSNA 1960 APATKPSRCG 1970 RGGAPSPRKD 1980 TGRAKDRKDP 1990 RKKKRGKEAG 2000 SAATLPSPRV 2010 STLPDSRAPH 2020 PGALATAKRS 2030 KAKARGKEAK 2040 KENRGKGGAV 2050 SKLMECMAAE 2060 EDFEPNQDSS 2070 FSEDEHLPRG 2080 GATERPLTPA 2090 PRSCIIDKEE 2100 LKDGLRVLIP 2110 MDDKLLYAGH 2120 VQTVHSPDIY 2130 RVVVEGERGN 2140 RPHIYCLEQL 2150 LQEAIIDVRP 2160 ASTRFLPQGT 2170 RIAAYWSQQY 2180 RCLYPGTVVR 2190 GLLDLEDDGD 2200 LITVEFDDGD 2210 TGRIPLSHIR 2220 LLPPDYKIQC 2230 AEPSPALLVP 2240 SAKRRSRKTS 2250 KDTGEGKEGA 2260 ATGPQEATGG 2270 KARGRGRKPS 2280 TKAKADRAVV 2290 LEEGAATNEL 2300 PSAPLALEPV 2310 STPNSKKSTP 2320 EPVDKRARAP 2330 KARSVSVQPS 2340 PGPPTFSSCP 2350 APEPFGELPT 2360 PATAPLVTMP 2370 VTMPATRPKP 2380 KKARATEGSG 2390 AKGPRRPGED 2400 DELLVKLDHE 2410 GVMSPKSKKA 2420 KEALLLREDP 2430 GPGAWPESTG 2440 LLSLGSYSPT 2450 VGSSEPKATW 2460 PKGLDGDLTQ 2470 EPGPGLPLED 2480 PGNSKSPDKA 2490 QAEQDGAEES 2500 ETTSSSSSSS 2510 SSSSSSSSSS 2520 SSSSSSSSGS 2530 ETEGEEDAEK 2540 NREDGRGAGG 2550 RTCSAASSRA 2560 SSPASSSSSS 2570 SSSSSSSSSS 2580 SSSSSSSSSS 2590 SSSSSSSSSS 2600 SSSSSSSSST 2610 TDEDSSCSSD 2620 DEAAPAPAAG 2630 PSTQPALPTK 2640 VSKPPSKARA 2650 SAHSPGKKAP 2660 PTTQPPPQPP 2670 PQPQQTLQPK 2680 TQTGAGAKSR 2690 PKKREGVHLP 2700 TTKELAKRQR 2710 LPSVENRPKI 2720 AAFLPARQLW 2730 KWFGKPTQRR 2740 GMKGKARKLF 2750 YKAIVRGKEM 2760 IRIGDCAVFL 2770 SAGRPNLPYI 2780 GRIQSMWESW 2790 GNNMVVRVKW 2800 FYHPEETSPG 2810 KQFHEGQHWD 2820 QKSGHNLPAA 2830 LRASSQRKDF 2840 MERALYQSSH 2850 VDENDVQTVS 2860 HKCLVVGLEQ 2870 YEQMLKTKKY 2880 QDSEGLYYLA 2890 GTYEPTTGMI 2900 FSTDGVPVLC

Gene Ontology

Classification GO ID Description
Molecular Function GO:0003682 chromatin binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.