Search Results

Overview

Uniprot ID	D3ZL24
Protein Name	Calpastatin
Gene Name	Cast
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
237	KSTGESSKAQSAGVT

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Protein Sequence

10 MSRPGPKPAA 20 SSRPRRGAAA 30 SHTQEHVNEK 40 NIGSSSKPAE 50 KKGSDEVTAS 60 SAATGTSPRM 70 STTGAKAVKI 80 ESEKSQSSEP 90 PVIHEKKPKG 100 KPKEGSETKF 110 QDAPSADGES 120 VAGGVTVATA 130 SDKVVVKSGV 140 NAALDDLIDT 150 LGECEDTNKD 160 DPPYTGPVVL 170 DPMDSTYLEA 180 LGIKEGTIPP 190 EYRKLLEKNE 200 AITGPLPDSP 210 KPMGIDHAID 220 ALSSDFTCSS 230 PTGKQTEKEK 240 STGESSKAQS 250 AGVTRSAVPP 260 QEKKRKVEEE 270 VMNDQALQAL 280 SDSLGTRQPD 290 PQSHLRQAKQ 300 VKEAKAKEER 310 QEKCGEDEDT 320 VPAEYRLKPA 330 KDKDGKPLLP 340 EPEETSKCLS 350 ESELIGELSA 360 DFVQPTYQEK 370 PSMPAAKIKK 380 GVVPDDAVET 390 LARSLGTRKE 400 DPEDEKSLVD 410 KVKEKAKEED 420 HEKLGEKEET 430 IPPDYRLEIV 440 KDKDGKPLLP 450 KEAEEQLPPL 460 SDDFLLDALS 470 QDFSSPANIL 480 SLGFEDAKLS 490 AAVSETVSQV 500 PAPSNHTAAP 510 PPGTERRDKE 520 LDDALDELSD 530 SLGQRQPDPD 540 ENKPLDDKVK 550 EKIKAEHSEK 560 LGERDDTIPP 570 EYRHLLDNDG 580 KDKPEKPLTK 590 NTEKPGQDQD 600 PIDALSEDLD 610 SCPPTTETSQ 620 NTTKEKGKKT 630 SSSKASKNEE 640 KTKDSSKKTE 650 EVPKPKVDED AT

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.