Search Results
Overview
| Uniprot ID | D3ZLK9 |
|---|---|
| Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Gene Name | Naxd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 85 | IVPALTSKKHKGQDG |
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Protein Sequence
10
MGIRCVAIRA
20
CGGGKIDTGV
30
PRMAVCPYGA
40
AAVVMALLSA
50
AIAFHCSPLL
60
AVLQRALSLH
70
TAHATKDMDN
80
LFQLVRNIVP
90
ALTSKKHKGQ
100
DGRIGIVGGC
110
QEYTGAPYFA
120
GISALKVGAD
130
LTHVFCAREA
140
APVIKSYSPE
150
LIVHPVLDSS
160
DAVEEVEKWL
170
PRLHALVVGP
180
GLGRDDLLLN
190
NVRGILESTK
200
ARDIPVVIDA
210
DGLWLIAQRP
220
ALVHGYQKAV
230
LTPNHVEFSR
240
LWDAVLSSPM
250
DTSNHSGSVL
260
KLSQALGNIT
270
IVQKGEQDLI
280
SNGQQVLVCN
290
QEGSSRRCGG
300
QGDLLSGSLG
310
VMAHWALRAG
320
PEKTNGSSPL
330
LVAAWGACTL
340
TRECNHLAFQ
350
KYGRSTTTTD
360
MIAEVGAAFS
KLFTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.