Search Results
Overview
| Uniprot ID | D3ZLU4 |
|---|---|
| Protein Name | Mitochondrial tRNA-specific 2-thiouridylase 1 |
| Gene Name | Trmu |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | ISCNKHIKFSCFHHY |
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base
Protein Sequence
10
MSALRHVVCA
20
LSGGVDSAVA
30
ALLLRRRGYQ
40
VTGVFMKNWD
50
SLDEQGICAA
60
DKDCEDAYKV
70
CQILDIPFHQ
80
VSYVKEYWND
90
VFSDFLNEYE
100
KGRTPNPDIS
110
CNKHIKFSCF
120
HHYAVDNLGA
130
DAVATGHYAR
140
TSLEDEEVFE
150
QKHTKRPDGL
160
FRNRFEVRNP
170
VKLLQAADSF
180
KDQTFFLSQV
190
SQDALRRTIF
200
PLGELTKDFV
210
KKIAAENRLH
220
HVLQKKESMG
230
ICFIGKRNLE
240
HFLLQYLQPR
250
PGKFISIEDN
260
RVLGTHKGWF
270
LYTLGQRAKI
280
SGLSEPWYVV
290
EKDGTKGDVL
300
VAPRVDHPAL
310
YRDLLRTNRV
320
HWIAEEPPAA
330
LVRDKMMECH
340
FRFRHQMALV
350
PCVLTLNQDG
360
TVWVTAVKAV
370
RGLALGQFAV
380
FYKGEECLGS
390
GKILRLGPSA
400
YTLQKGKNRT
410
RVAPEVSSDS
PGLHPTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0061708 | tRNA-5-taurinomethyluridine 2-sulfurtransferase activity |
| Biological Process | GO:0008033 | tRNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.