Search Results

Overview

Uniprot ID	D3ZMQ0
Protein Name	MAX gene-associated protein
Gene Name	Mga
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1888	VRKVRPQKYVEVKVE
2758	TLWRPMPKLAPLGLK

Function

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor

Protein Sequence

10 MEEKQQIILA 20 NQDGGTVTGA 30 APTFFVILKQ 40 PGNGKTDQGI 50 LVTNRDARAL 60 LSRESSPGKS 70 KEKICLPADC 80 TVGKITVTLD 90 NNSMWNEFHN 100 RSTEMILTKQ 110 GRRMFPYCRY 120 WITGLDSNLK 130 YILVMDISPV 140 DSHRYKWNGR 150 WWEPSGKAEP 160 HILGRVFIHP 170 ESPSTGHYWM 180 HQPVSFYKLK 190 LTNNTLDQEG 200 HIILHSMHRY 210 LPRLHLVPAE 220 KATEVIQLNG 230 PGVHTFTFPQ 240 TEFFAVTAYQ 250 NIQITQLKID 260 YNPFAKGFRD 270 DGLSSKPQRD 280 GKQRNSSDQE 290 GNSVSSSPGH 300 RVRLTEGEGS 310 EIHSGDFDPV 320 LRGHETSSLG 330 LEKAPNNVKQ 340 DFLGFMNTDS 350 THEVPQLKRE 360 ISESHVSSFE 370 ENSQISSPLN 380 PNGNFNVVIK 390 EEPLDDYDYE 400 LGECPEGITV 410 KQEETDEETD 420 VYSNSDDDPI 430 LEKQLKRHNK 440 VDNLEADHSS 450 YKWLPNSPGV 460 AKAKMFKLDA 470 GKMPVVYLEP 480 CAVTKSTVKI 490 SELPDNMLST 500 SRKDKSMLAE 510 LEYLPAYIEN 520 SDETGFCLSK 530 DSENSLRKHS 540 SDLRMVQKYT 550 LLKEPHWKYP 560 DIFDSSSTEK 570 THDSSKGSTE 580 DSFSGKEDLG 590 KKRTTMLKMA 600 IPSKTVNASQ 610 SASPNTPGKR 620 GRPRKLRLSK 630 AGRPPKNTGK 640 SLTASKNIPV 650 GPGNTFPDVK 660 PDLEDVDGVL 670 FVSFESKEAL 680 DIHAVDGTTE 690 EPSSVQTTTT 700 NDSGSRTRIS 710 QLEKELIEDL 720 KSLRHKQVIH 730 PALQEVGLKL 740 NSVDPTMSID 750 LKYLGVQLPL 760 APATSFPLWN 770 VTGTNPASPD 780 AGFPFVSRTG 790 KTNDFTKIKG 800 WRGKFHNASA 810 SRNEGGNSET 820 SLKNRSAFCS 830 DKLDEYLENE 840 GKLMETSMGF 850 SSNAPTAPTS 860 PVVYQLPTKS 870 TSYVRTLDSV 880 LKKQSTISPS 890 TSHSVKPHSV 900 TTASRKTKAQ 910 NKQTTVSGRT 920 KSSYKSILPY 930 PVSPKQKNSH 940 VSPGDKITKN 950 SLSSASDNQV 960 TNLVVPSIDE 970 SAFPKQISLR 980 QAQQQHIQQQ 990 GTRPPGLSKS 1000 QVKLMDLEDC 1010 ALWEGKPRTY 1020 ITEERADVSL 1030 TTLLTAQASL 1040 KTKPIHTIIR 1050 KRAPPCNNDF 1060 CRLGCVCSSL 1070 ALEKRQPAHC 1080 RRPDCMFGCT 1090 CLKRKVVLVK 1100 GGSKTKHLHK 1110 KAANRDPLFY 1120 DTLGEGGREG 1130 GGGVREDEEQ 1140 LKEKKKRKKL 1150 EYTVCEAEPE 1160 QPVRHYPLWV 1170 KVDGEVDPEP 1180 VYIPTPSVIE 1190 PIKPLVLPQP 1200 DASSTTIKGK 1210 LTPGIKPTRA 1220 YTPKPNPIRE 1230 EDKDPVYLYF 1240 ESMMTCARVR 1250 VYERKKDEQR 1260 QLSPPLSPSS 1270 SFQQQSSCYS 1280 SPENHATKEL 1290 DSEQTLKQLI 1300 CDLEDDSDKS 1310 QEKTWKSSCN 1320 EGESSSTSYV 1330 HQRSPGGPTK 1340 LIEIISDCNW 1350 EEDRNKILSI 1360 LSQHINSNMP 1370 QSLKVGSFII 1380 ELASQRKCRG 1390 EKTPPVYSSR 1400 VKISMPSSQD 1410 QDDMAEKSGS 1420 ETPDGPLSPG 1430 KMDDISPVQT 1440 DALDSVRERL 1450 HGGKGLPFYA 1460 GLSPSGKLVA 1470 YKRKPSSTTS 1480 GLIQVASNAK 1490 VAASRKPRTL 1500 LPSTSNSKMA 1510 SSGPTTNRSG 1520 KNLKAFVPAK 1530 RPIENAPQIP 1540 VTTPQISPNN 1550 VKRTGPRLLL 1560 IPVQQGSPTL 1570 RPIPNPQLQG 1580 QRMVLQPVRS 1590 PSGMNLFRHP 1600 NGQIVQLLPL 1610 HQIRGSNTQP 1620 SLQPVVFRNP 1630 GSVVGIRLPT 1640 PCKSSETPSS 1650 SSSSAFSVMS 1660 PVIQAVGSSP 1670 TVNVISQAPS 1680 LLSSGSSFVS 1690 QAGTLTLRIS 1700 PPETQNLASK 1710 TASESKITPS 1720 TGGQPVGTAS 1730 LIPLQSGSFA 1740 LLQLPGQKPV 1750 PNSVLQHVAS 1760 LQIKKESQNT 1770 DQKDESNSIK 1780 REKETKKALS 1790 SKDEVVDPEA 1800 NIMKQNSGII 1810 ASEDTFNNSL 1820 DDRGDLLDEE 1830 SLREDTRPYE 1840 YSYSTGSHTD 1850 EDKDGDEESG 1860 NKNENSPKEK 1870 QTVPEVRAGS 1880 ENINIMTLQN 1890 VRKVRPQKYV 1900 EVKVEQQQGS 1910 ENPDDFLVLS 1920 KEESKFELSG 1930 SQVKEQKSNS 1940 QTEAKKDCED 1950 SLGKDSLRER 1960 WRKHLKGPLT 1970 HKYVGISQDF 1980 KKEADVQLFT 1990 EMKPCQDNSE 2000 RDISELLGKS 2010 GTIESGGIFK 2020 TEDGSWSGIS 2030 SSAAFSIIPR 2040 RATKGRRGSR 2050 RFQGHFLLSK 2060 EHMKPKQQAN 2070 GGRSSADFTV 2080 LDLEDEDEED 2090 ENEKTDDSID 2100 EIVDVVSGYQ 2110 SEEVDVEKNN 2120 YVDYIEDDEQ 2130 VDVETVEELS 2140 EEINFTYKKT 2150 TAAHTQSFRQ 2160 QCHSLISADE 2170 KASEKSRKVS 2180 LISSKLKDDC 2190 WSDKPHKETE 2200 AFAYYRRTHT 2210 ANERRRRGEM 2220 RDLFEKLKIT 2230 LGLLHSSKVS 2240 KSLILNRAFS 2250 EIQGLTDQAD 2260 KLIGQKNLLS 2270 RKRSILIRKV 2280 SSLSGKTEEV 2290 VLKKLEYIYA 2300 KQQALEAQKR 2310 KKKMGSDEFG 2320 LSPRISTQLE 2330 GSSSSVDLGQ 2340 MFMSNRRGKP 2350 LILSRRRDQA 2360 TENASPSDTP 2370 HSSANLVMTP 2380 QGQLLTLKGP 2390 LFSAPVVAVS 2400 PALLEAGLKP 2410 QVASSTMAQS 2420 ENDDLFMMPR 2430 IVNVTSLAAE 2440 EDLGGMSGNK 2450 YLHEVPDGKP 2460 ALDHLRDVSG 2470 NEASSLKDTE 2480 RISSRGNHRD 2490 SRMALGPTQV 2500 FLANKDSGFP 2510 HVPDVSTMQA 2520 AQEFIPKKMS 2530 GDLRGHRHKW 2540 KECELRGERL 2550 KSKESQFHKL 2560 KMKDLKDSSI 2570 EMELRKVASA 2580 IEEAALDPSE 2590 LLTNMEDEDD 2600 TDETLTSLLN 2610 EIAFLNQQLN 2620 DDSGLAELSG 2630 SLDTEFPGDA 2640 QQAFISKLAP 2650 GNRSAFQVGH 2660 LGTGVKELPD 2670 VQEESESISP 2680 LLLHLEDDDF 2690 SENEKQLGDT 2700 ASEPDVLKIV 2710 IDSEIKDSLV 2720 SHRKSSDGGQ 2730 STSGLPAEPE 2740 SVSSPPILHM 2750 KTGPENSSTD 2760 TLWRPMPKLA 2770 PLGLKVANPP 2780 SDADGQSLKV 2790 MPALAPIAAK 2800 VGSVGHKMNT 2810 TGSDQEGRGS 2820 KMMPTLAPVV 2830 TKLGNSGVPS SSSGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071339	MLL1 complex
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0046983	protein dimerization activity
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045893	positive regulation of DNA-templated transcription

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.