Search Results

Overview

Uniprot IDD3ZN95
Protein NameHost cell factor 1
Gene NameHcfc1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
2016 RWLQETSKDSSGTKP
345 SGRDGYRKAWNNQVC
813 SGTGAPAKIITAVPK
820 KIITAVPKIATGHGQ
836 GVTQVVLKGAPGQPG

Function

Transcriptional coregulator (PubMed:24250814). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (By similarity). Involved in control of the cell cycle (By similarity). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (PubMed:24250814). May negatively modulate transcriptional activity of FOXO3 (PubMed:21909281)

Protein Sequence

10 MASAVSPANL 20 PAVLLQPRWK 30 RVVGWSGPVP 40 RPRHGHRAVA 50 IKELIVVFGG 60 GNEGIVDELH 70 VYNTATNQWF 80 IPAVRGDIPP 90 GCAAYGFVCD 100 GTRLLVFGGM 110 VEYGKYSNDL 120 YELQASRWEW 130 KRLKAKTPKN 140 GPPPCPRLGH 150 SFSLVGNKCY 160 LFGGLANDSE 170 DPKNNIPRYL 180 NDLYILELRP 190 GSGVVAWDIP 200 ITYGVLPPPR 210 ESHTAVVYTE 220 KDNKKSKLVI 230 YGGMSGCRLG 240 DLWTLDIETL 250 TWNKPSLSGV 260 APLPRSLHSA 270 TTIGNKMYVF 280 GGWVPLVMDD 290 VKVATHEKEW 300 KCTNTLACLN 310 LDTMAWETIL 320 MDTLEDNIPR 330 ARAGHCAVAI 340 NTRLYIWSGR 350 DGYRKAWNNQ 360 VCCKDLWYLE 370 TEKPPPPARV 380 QLVRANTNSL 390 EVSWGAVATA 400 DSYLLQLQKY 410 DIPATAATAT 420 SPTPNPVPSV 430 PANPPKSPAP 440 AAAAPAVQPL 450 TQVGITLVPQ 460 AAAAPPSTTT 470 IQVLPTVPGS 480 SISVPTAART 490 QGVPAVLKVT 500 GPQATTGTPL 510 VTMRPASQAG 520 KAPVTVTSLP 530 ASVRMVVPTQ 540 SAQGTVIGSN 550 PQMSGMAALA 560 AAAAATQKIP 570 PSSAPTVLSV 580 PAGTTIVKTV 590 AVTPGTTTLP 600 ATVKVASSPV 610 MVSNPATRML 620 KTAAAQVGTS 630 VSSAANTSTR 640 PIITVHKSGT 650 VTVAQQAQVV 660 TTVVGGVTKT 670 ITLVKSPISV 680 PGGSALISNL 690 GKVMSVVQTK 700 PVQTSAVTGQ 710 ASTGPVTQII 720 QTKGPLPAGT 730 ILKLVTSADG 740 KPTTIITTTQ 750 ASGAGTKPTI 760 LGISSVSPST 770 TKPGTTTIIK 780 TIPMSAIITQ 790 AGATGVTSSP 800 GIKSPITIIT 810 TKVMTSGTGA 820 PAKIITAVPK 830 IATGHGQQGV 840 TQVVLKGAPG 850 QPGTILRTVP 860 MGGVRLVTPV 870 TVSAVKPAVT 880 TLVVKGTTGV 890 TTLGTVTGTV 900 STSLAGAGAH 910 STSASLATPI 920 TTLGTIATLS 930 SQVINPTAIT 940 VSAAQTTLTA 950 AGGLTTPTIT 960 MQPVSQPTQV 970 TLITAPSGVE 980 AQPVHDLPVS 990 ILASPTTEQP 1000 TATVTIADSG 1010 QGDVQPGTVT 1020 LVCSNPPCET 1030 HETGTTNTAT 1040 TTVVANLGGH 1050 PQPTQVQFVC 1060 DRQEAAASLV 1070 TSAVGQQNGN 1080 VVRVCSNPPC 1090 ETHETGTTNT 1100 ATTATSNMAG 1110 QHGCSNPPCE 1120 THETGTTSTA 1130 TTAMSSMGTG 1140 QQRDARRATN 1150 TPTVVRITVA 1160 PGALERAQGT 1170 VKPPCQTQQT 1180 NMTSTTMTVQ 1190 ATGAPCSAGP 1200 LLRPSVALET 1210 GSHSPAFVQL 1220 ALPSVRVGLS 1230 GPSSKDVPTG 1240 RQPETYHTYT 1250 TNTPTTARSI 1260 MVAGELGTAR 1270 VVPTSQYDCL 1280 QASSPSSTMT 1290 MTALEALLCP 1300 SATVTQVCSN 1310 PPCETHETGT 1320 TNTATTSNAG 1330 SAQRVCSNPP 1340 CETHETGTTH 1350 TATTATSNGG 1360 AGQPEGGQQP 1370 ASGHPCETHQ 1380 TTSTGTTMSV 1390 SVGALIPDAT 1400 PSHGTLESGL 1410 EVVAVPTVTS 1420 QAGATLLASF 1430 STQRVCSNPP 1440 CETHETGTTH 1450 TATTVTSNMS 1460 SNQDPPPAAS 1470 DQGEVASTQG 1480 DSTNITSASA 1490 ITTTVSSTLP 1500 RAVTTVTQST 1510 PVPGPSVPPP 1520 EELQVSPGPR 1530 QQLPPRQLLQ 1540 SASTPLMGES 1550 AEVLSASQTP 1560 ELQAAVDLSS 1570 TGDPSSVQEP 1580 TTSAVVATVV 1590 VQPPQPTQSE 1600 VDQLSLPQEL 1610 MAEAQAGTTT 1620 LMVTGLTPEE 1630 LAVTAAAEAA 1640 AQAAATEEAQ 1650 ALAIQAVLQA 1660 AQQAVMGTGE 1670 PMDTSEAAAA 1680 VTQAELGHLS 1690 AEGQEGQATT 1700 IPIVLTQQEL 1710 AALVQQQQQL 1720 QEAQAQAQQQ 1730 HHLPTEALAP 1740 ADSLNDPSIE 1750 SNCLNELASA 1760 VPSTVALLPS 1770 TATESLAPSN 1780 TFVAPQPVVV 1790 ASPAKMQAAA 1800 TLTEVANGIE 1810 SLGVKPDLPP 1820 PPSKAPIKKE 1830 NQWFDVGVIK 1840 GTSVMVTHYF 1850 LPPDDAVQSD 1860 DDSGTVPDYN 1870 QLKKQELQPG 1880 TAYKFRVAGI 1890 NACGRGPFSE 1900 ISAFKTCLPG 1910 FPGAPCAIKI 1920 SKSPDGAHLT 1930 WEPPSVTSGK 1940 IIEYSVYLAI 1950 QSSQASGEPK 1960 SSTPAQLAFM 1970 RVYCGPSPSC 1980 LVQSSSLSNA 1990 HIDYTTKPAI 2000 IFRIAARNEK 2010 GYGPATQVRW 2020 LQETSKDSSG 2030 TKPASKRPMS SPEM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030425 dendrite
Cellular Component GO:0000123 histone acetyltransferase complex
Cellular Component GO:0035097 histone methyltransferase complex
Cellular Component GO:0071339 MLL1 complex
Cellular Component GO:0044665 MLL1/2 complex
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0044545 NSL complex
Cellular Component GO:0000228 nuclear chromosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0048188 Set1C/COMPASS complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0001835 blastocyst hatching
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0050821 protein stabilization
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0043254 regulation of protein-containing complex assembly
Biological Process GO:0019046 release from viral latency

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.