Search Results
Overview
| Uniprot ID | D3ZNF4 |
|---|---|
| Protein Name | F-box-like/WD repeat-containing protein TBL1XR1 |
| Gene Name | Tbl1xr1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | RQQAYRDKLAQQHAA |
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation
Protein Sequence
10
MSISSDEVNF
20
LVYRYLQESG
30
FSHSAFTFGI
40
ESHISQSNIN
50
GALVPPAALI
60
SIIQKGLQYV
70
EAEVSINEDG
80
TLFDGRPIES
90
LSLIDAVMPD
100
VVQTRQQAYR
110
DKLAQQHAAA
120
AAAAAAATNQ
130
QGSAKNGENT
140
ANGEENGAHT
150
IANNHTDMME
160
VDGDVEIPPN
170
KAVVLRGHES
180
EVFICAWNPV
190
SDLLASGSGD
200
STARIWNLSE
210
NSTSGPTQLV
220
LRHCIREGGQ
230
DVPSNKDVTS
240
LDWNSEGTLL
250
ATGSYDGFAR
260
IWTKDGNLAS
270
TLGQHKGPIF
280
ALKWNKKGNF
290
ILSAGVDKTT
300
IIWDAHTGEA
310
KQQFPFHSAP
320
ALDVDWQSNN
330
TFASCSTDMC
340
IHVCKLGQDR
350
PIKTFQGHTN
360
EVNAIKWDPT
370
GNLLASCSDD
380
MTLKIWSMKQ
390
DNCVHDLQAH
400
NKEIYTIKWS
410
PTGPGTNNPN
420
ANLMLASASF
430
DSTVRLWDVD
440
RGICIHTLTK
450
HQEPVYSVAF
460
SPDGRYLASG
470
SFDKCVHIWN
480
TQTGALVHSY
490
RGTGGIFEVC
500
WNAAGDKVGA
510
SASDGSVCVL
DLRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0060612 | adipose tissue development |
| Biological Process | GO:0001835 | blastocyst hatching |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0060613 | fat pad development |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0035264 | multicellular organism growth |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090207 | regulation of triglyceride metabolic process |
| Biological Process | GO:0002021 | response to dietary excess |
| Biological Process | GO:0050872 | white fat cell differentiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.