Overview
| Uniprot ID | D3ZNY3 |
|---|
| Protein Name | - |
|---|
| Gene Name | Mmaa |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 78 |
HTEGLSDKEQRFVDR |
Function
GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP
Protein Sequence
10
MTIPTLLLSP
20
YRRLLTRLSR
30
VPSPQLLHSS
40
LPTLHPRDAL
50
PNSFGHHCSK
60
RVLLSDGFRR
70
TLCIRATLKD
80
HTEGLSDKEQ
90
RFVDRLYMGL
100
VQGQRACLAE
110
AITLVESTHT
120
RKKELAQVLL
130
QRVLAHQRER
140
ELQNHGKPFT
150
FRVGLSGPPG
160
AGKSTFIECF
170
GKMLTERGHR
180
LSVLAVDPSS
190
CTSGGSLLGD
200
KTRMTELSRD
210
MNAYIRPSPT
220
SGTLGGVTRT
230
TNEAIVLCEG
240
GGYDIILIET
250
VGVGQSEFAV
260
ADMVDMFVLL
270
LPPAGGDELQ
280
GIKRGIIEMA
290
DLVVITKSDG
300
DLVVPARRIQ
310
AEYVSALKLL
320
RRRSEVWRPK
330
VIRISARSGE
340
GITEMWDIMR
350
EFQHRMLASG
360
ELAAKRQTQH
370
KVWMWNLIQE
380
NVLEHFKTHP
390
SIREQIPLME
400
REVLSGALSP
410
GRAADLLLKA
FKSRH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.