Overview
| Uniprot ID | D3ZQI4 |
|---|
| Protein Name | AN1-type zinc finger protein 1 |
|---|
| Gene Name | Zfand1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
PRMAATQKLVRDIVD |
| 122 |
VRDIVDAKAGGAASK |
Function
Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress. Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome. This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy
Protein Sequence
10
MAELDIGQHC
20
QVQHCRQRDF
30
LPFVCDGCSG
40
IFCLEHRSKD
50
SHGCPEANVI
60
KERLKTDEHK
70
SYPCSFKGCA
80
EVELVAVICP
90
YCEKNFCLRH
100
RHQSDHECEK
110
LEIPKPRMAA
120
TQKLVRDIVD
130
AKAGGAASKG
140
RKGAKSSRTA
150
AKVALMKLKM
160
HADGDKSLPQ
170
KERTSRYTYQ
180
RGAKRKAKPC
190
SSAYGGASGR
200
LWTLQRLLVS
GMKTTS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Molecular Function |
GO:0070628 |
proteasome binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:1903843 |
cellular response to arsenite ion |
| Biological Process |
GO:0090316 |
positive regulation of intracellular protein transport |
| Biological Process |
GO:0035617 |
stress granule disassembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.