Search Results
Overview
| Uniprot ID | D3ZRN2 |
|---|---|
| Protein Name | Mediator of RNA polymerase II transcription subunit 1 |
| Gene Name | Med1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1295 | QHGSSKGKSPSRNKK |
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
Protein Sequence
10
MKAQGETEES
20
EKLSKMSSLL
30
DRLHAKFNQS
40
RPWSETIKLV
50
RQVMEKRVVM
60
SSGGHQHLVS
70
CLETLQKALK
80
VTSLPAMTDR
90
LESIARQNGL
100
GSHLSASGTE
110
CYITSDMFYV
120
EVQLDPAGQL
130
CDVKVAHHGE
140
NPVVCVDISL
150
ESMGEKNFDE
160
FSKHLKGLVN
170
LYNLPGDNKL
180
KTKMYLALQS
190
LEQDLSKMAI
200
MYWKATNATP
210
LDKILHGSVG
220
YLTPRSGGHL
230
MNMKYYASPS
240
DLLHDTTASP
250
ITLHEKNVPR
260
SLGMNASVTI
270
EGTSAMYKLP
280
IAPLIMGSHP
290
ADNKWTPSFS
300
AVTSANSVDL
310
PACFFLKFPQ
320
PIPVSKAFVQ
330
KLQNCTGIPL
340
FETPPTYLPL
350
YELITQFELS
360
KDPDPLPLNH
370
NMRFYAALPG
380
QQHCYFLNKD
390
APLPDGQSLQ
400
GTLVSKITFQ
410
HPGRVPLILN
420
MIRHQVAYNT
430
LIGSCVKRTI
440
LKEDSPGLLQ
450
FEVCPLSESR
460
FSVSFQHPVN
470
DSLVCVVMDV
480
QDSTHVSCKL
490
YKGLSDALIC
500
TDDFIAKVVQ
510
RCMSIPVTMR
520
AIRRKAETIQ
530
ADTPALSLIA
540
ETVEDMVKKN
550
LPPASSPGYG
560
MTTGSNPMSG
570
TTTPTNTFPG
580
GPITTLFNMS
590
MSIKDRHESV
600
GHGEDFSKVS
610
QNPILTSLLQ
620
ITGNGGSTIG
630
SSPTPPHHTP
640
PPVSSMAGNT
650
KNHPMLMNLL
660
KDNPAQDFST
670
LYGSSPLERQ
680
NSSSGSPRME
690
MCSGSNKTKK
700
NKSSRVPPDK
710
PKHQTEDDFQ
720
RELFSMDVDS
730
QNPMFDVSMT
740
ADALDTPHIT
750
PAPSQCSTPP
760
TTYPQPVSHP
770
QPSIQRMGRL
780
SSSDSIGPDV
790
TDILSDIAEE
800
ASKLPSTSDD
810
CPPIGTPVRD
820
SSSSGHSQSA
830
LFDSDVFQTN
840
NNENPYTDPA
850
DLIADAAGSP
860
SSDSPTNHFF
870
PDGVDFNPDL
880
LNSQSQSGFG
890
EEYFDESSQS
900
GDNDDFKGFA
910
SQALNTLGMP
920
MLGGDNGESK
930
LKGSSQADTV
940
DFSILSVAGK
950
ALGAADLLEH
960
HSGSQSPLLT
970
TGELGKEKTQ
980
KRVKEGNGMG
990
ASSGSGPGSD
1000
SKPGKRSRTP
1010
SNDGKSKDKP
1020
PKRKKADTEG
1030
KSPSHSSNRP
1040
FTPPTSTGGS
1050
KSPGSSGRCQ
1060
TPPGVATPPI
1070
PKITIQIPKG
1080
TVMVGKPSSH
1090
SQYSSSGSVS
1100
SSGSKSHHSH
1110
SSSSSSLSSA
1120
STSGKMKSSK
1130
SEGSSSAKLS
1140
GSMYSSQGSS
1150
GSSQSKNSSQ
1160
TGGKPGSSPI
1170
TKHGLSSGSS
1180
STKMKPQGKP
1190
SSLMNPSISK
1200
PNISPSHSRP
1210
PGGSDKLASP
1220
MKPVPGTPPS
1230
SKAKSPISSG
1240
SGSSHVSGTS
1250
SSSGMKSSSG
1260
SGSSGSLSQK
1270
TPPASNSCTP
1280
SSSSFSSSGS
1290
SMSSSQNQHG
1300
SSKGKSPSRN
1310
KKPSLTAVID
1320
KLKHGVVTSG
1330
PGGEDPIDSQ
1340
MGASTNSSNH
1350
PMSSKHNMSG
1360
GEFQSKREKS
1370
DKDKSKVSTS
1380
GGSVDSSKKT
1390
SESKNVGSTG
1400
VAKIIISKHD
1410
GGSPSIKAKV
1420
TLQKPGDSGG
1430
EGLRPQIASS
1440
KNYGSPLISG
1450
STPKHERGSP
1460
SHSKSPAYTP
1470
QNVDSESESG
1480
SSIAERSYQN
1490
SPSSDDGVRP
1500
LPEYSTEKHK
1510
KHKKEKKKVK
1520
DKDRDRDRDK
1530
DRDKKKSHSI
1540
KPENWSKSPI
1550
SSDQTSSMTN
1560
NPILSADRPS
1570
RLSPDFMIGE
1580
EDDDLMDVAL
IGN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Biological Process | GO:0035162 | embryonic hemopoiesis |
| Biological Process | GO:0035116 | embryonic hindlimb morphogenesis |
| Biological Process | GO:0001892 | embryonic placenta development |
| Biological Process | GO:0048822 | enucleate erythrocyte development |
| Biological Process | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation |
| Biological Process | GO:0048821 | erythrocyte development |
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0002088 | lens development in camera-type eye |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0060745 | mammary gland branching involved in pregnancy |
| Biological Process | GO:0060744 | mammary gland branching involved in thelarche |
| Biological Process | GO:0033598 | mammary gland epithelial cell proliferation |
| Biological Process | GO:0035855 | megakaryocyte development |
| Biological Process | GO:0030224 | monocyte differentiation |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010839 | negative regulation of keratinocyte proliferation |
| Biological Process | GO:0045665 | negative regulation of neuron differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030518 | nuclear receptor-mediated steroid hormone signaling pathway |
| Biological Process | GO:0035357 | peroxisome proliferator activated receptor signaling pathway |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045648 | positive regulation of erythrocyte differentiation |
| Biological Process | GO:0070318 | positive regulation of G0 to G1 transition |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:2000347 | positive regulation of hepatocyte proliferation |
| Biological Process | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway |
| Biological Process | GO:0045618 | positive regulation of keratinocyte differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0060335 | positive regulation of type II interferon-mediated signaling pathway |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:2001141 | regulation of RNA biosynthetic process |
| Biological Process | GO:0070562 | regulation of vitamin D receptor signaling pathway |
| Biological Process | GO:0003406 | retinal pigment epithelium development |
| Biological Process | GO:0006590 | thyroid hormone generation |
| Biological Process | GO:0002154 | thyroid hormone receptor signaling pathway |
| Biological Process | GO:0003222 | ventricular trabecula myocardium morphogenesis |
| Cellular Component | GO:0070847 | core mediator complex |
| Cellular Component | GO:0016592 | mediator complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0140296 | general transcription initiation factor binding |
| Molecular Function | GO:0035035 | histone acetyltransferase binding |
| Molecular Function | GO:0050693 | LBD domain binding |
| Molecular Function | GO:0030331 | nuclear estrogen receptor binding |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0042974 | nuclear retinoic acid receptor binding |
| Molecular Function | GO:0046966 | nuclear thyroid hormone receptor binding |
| Molecular Function | GO:0042809 | nuclear vitamin D receptor binding |
| Molecular Function | GO:0042975 | peroxisome proliferator activated receptor binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0001223 | transcription coactivator binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006702 | androgen biosynthetic process |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0009887 | animal organ morphogenesis |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0043010 | camera-type eye development |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| Biological Process | GO:0071383 | cellular response to steroid hormone stimulus |
| Biological Process | GO:0097067 | cellular response to thyroid hormone stimulus |
| Biological Process | GO:0035050 | embryonic heart tube development |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.