Search Results
Overview
| Uniprot ID | D3ZRX9 |
|---|---|
| Protein Name | Calponin |
| Gene Name | Cnn2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | VKNRLLSKYDPQKEA |
| 30 | LSKYDPQKEAELRSW |
| 74 | LQPGSVPKINRSMQN |
| 8 | MSSTQFNKGPSYGLS |
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity
Protein Sequence
10
MSSTQFNKGP
20
SYGLSAEVKN
30
RLLSKYDPQK
40
EAELRSWIEG
50
LTGLSIGPDF
60
QKGLKDGVIL
70
CTLMNKLQPG
80
SVPKINRSMQ
90
NWHQLENLSN
100
FIKAMVSYGM
110
NPVDLFEAND
120
LFESGNMTQV
130
QVSLLALAGK
140
MGTNKCASQS
150
GMTAYGTRRH
160
LYDPKNHILP
170
PMDHCTISLQ
180
MGTNKCASQV
190
GMTAPGTRRH
200
IYDTKLGTDK
210
CDNSSMSLQM
220
GYTQGANQSG
230
QVFGLGRQIY
240
DPKYCPQGSA
250
VDGAPTGGDG
260
QGEAPEYLSY
CQEEASY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0031032 | actomyosin structure organization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.