Search Results

Overview

Uniprot IDD3ZTA3
Protein NameGerminal-center associated nuclear protein
Gene NameMcm3ap
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
553 ATGSLLNKSSPVKKP

Function

As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations

Protein Sequence

10 MNPVNPFSGQ 20 QPGAFAVSSS 30 ATGTFQTKSP 40 FRFGQPSLFG 50 QNNQASKSLG 60 FSQVPSFATP 70 SGGSHSSSLP 80 AFGLTQTSSV 90 GLFSGLESTP 100 SFAATSGPSS 110 SSVPGNTAFS 120 FKSASSVGVF 130 SSGPTFGPET 140 GDVAGSGFRK 150 TEFKFKPLEN 160 AVFKPILGAE 170 SEPEKTQSQI 180 ASGFFTFSHP 190 VSSGSGGLTP 200 FSFPQVTNSS 210 ATSSSFIFSK 220 PVTSNTSAFA 230 PALSNQNIEE 240 EKRGPKSVFG 250 GLNSSFSTFP 260 MASPGSLGEP 270 FPTNKTSIRQ 280 GGEEAISQVE 290 SHPALMKGLK 300 RKEDQDRSPR 310 RHCHEAAEDS 320 DPLSRGDHPP 330 DKRPVRLNRP 340 RGGTLFGRTI 350 QEVFKSNKEA 360 GRLGSKESKK 370 DSGFVESGES 380 DHVAIPGGSQ 390 STLVTSRLPA 400 VNKEEETEGR 410 DEKEDSLRGT 420 SVRQSKRSES 430 TDSLGGMSSL 440 ELTAIQCKNI 450 PDYLNDRAIL 460 EKHFSKIAKV 470 QRVFTRRSKK 480 LAVIHFFDHA 490 SAALARKKGK 500 GLHKDMAIFW 510 HKKKISPSKK 520 PFSLKEKQLG 530 EGEASQGIED 540 SPFQHSPLGK 550 PIVRPATGSL 560 LNKSSPVKKP 570 GLLKIHQFEA 580 DPFDSGSEGS 590 EGLGSCVSSL 600 STLIGTVADT 610 SEEKYRLLDQ 620 RDRIMRQARV 630 KRTDLDKARA 640 FVGTCPDMCP 650 EKERYLRETR 660 SQLSVFEVVP 670 GTDQVDHAAA 680 VKEYSRSSAD 690 QEEPLPHELR 700 PSAVLSRTMD 710 YLVTQIMDQK 720 EGSLRDWYDF 730 VWNRTRGIRK 740 DITQQHLCDP 750 LTVSLIEKCT 760 RFHIHCAHFM 770 CEEPMSSFDA 780 KINNENMTKC 790 LQSLKEMYQD 800 LRNKGVFCAS 810 EAEFQGYNVL 820 LNLNKGDILR 830 EVQQFHPDVR 840 NSPEVDFAVQ 850 AFAALNSNNF 860 VRFFKLVQSA 870 SYLNACLLHC 880 YFNQIRKDAL 890 RALNVAYTVS 900 TQRSTVFPLD 910 GVVRMLLFRD 920 CEEATSFLNY 930 HGLTVADGCV 940 ELNRSAFLEP 950 EGLYKARKSV 960 FIGRKLTVSV 970 GEVVNGGPLP 980 PVPRHTPVCS 990 FNSQNKYVGE 1000 SLATELPISA 1010 QRSGGDSAGG 1020 GRGEEVEAEV 1030 DVPPLAVLPQ 1040 LPPAPSATPV 1050 PHVQPLTQAV 1060 TPSLFQASTQ 1070 PEVLLPKPVP 1080 VYSDSDLVQV 1090 VDELIQEALQ 1100 VDCEEVSSAG 1110 AAYVAAALGV 1120 SNAAVEDLIT 1130 AATTGILRHV 1140 AAEEVSMERQ 1150 RVEEEKRRAE 1160 EERLKQEREL 1170 MLTQLSKGLA 1180 AELTELTVTE 1190 CVWETCSQEL 1200 KSAVETDQKV 1210 RVARCCEAVC 1220 THLVDLFLAE 1230 EIFQTAKETL 1240 QELQCFCKYL 1250 QRWRGAVAAR 1260 KKLRRQMRAF 1270 PAAPCCVDVN 1280 DRLQALVPSA 1290 ECPITEENLA 1300 KGLLDLGHAG 1310 KVGISCTRLR 1320 RLRNKTAHQM 1330 KVQHFHQQLL 1340 SNAAWAPLDL 1350 PSFVAEHLPV 1360 KQKRIFWKLV 1370 LVLPDGEEQT 1380 PESPGRILEN 1390 WLKVKFTGDG 1400 SLVDDTRDNA 1410 GDIQTLSVFN 1420 TLSSKGDQTV 1430 SVNVCIKVAR 1440 GTLSDSALDA 1450 VETRKDLLGA 1460 SGLMLLLPPK 1470 VKSEDVAEED 1480 LYWLSALLQL 1490 KQLLQAKPFQ 1500 PALPLVVLVP 1510 SSRGDSTGKG 1520 VEDGLMLQDL 1530 ISAKLISDYI 1540 VVEIPDFVND 1550 LHGTVKVSGA 1560 VQWLISRCPQ 1570 ALDLCCQTLI 1580 QYVEDGISRE 1590 FSGRFFHDRR 1600 ERRLGSLASQ 1610 EPSAIIELFN 1620 SVLQFLASVV 1630 SSEQLGDISW 1640 PVTEFAEVGG 1650 SQLLPHLHWN 1660 SPEHLAWLKQ 1670 AVLGFQLPQM 1680 DLPPPAALWL 1690 PVCSMVIQYT 1700 SQIPSSCRTQ 1710 PVLRSQVESL 1720 LCRTYQKWKS 1730 KSLCPGQQSG 1740 PSVAEIPWDD 1750 IITLCINHKL 1760 RDWTPPRLPV 1770 TLDALSEDGQ 1780 ICVYFFKNRL 1790 RKYTVPLSWE 1800 QARMQTQREL 1810 QLSQGWFEDQ 1820 LQQWLSRDSQ 1830 AFTESARLPL 1840 YLPQTLVSYP 1850 DAIKTQTKVK 1860 TSTSPQNAGT 1870 GDHVRFSEAS 1880 DTSLTEKLKH 1890 LERLIQSSRA 1900 EEAASELHLS ALLDMVDI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003676 nucleic acid binding
Molecular Function GO:0061733 protein-lysine-acetyltransferase activity
Biological Process GO:0002376 immune system process
Biological Process GO:0051028 mRNA transport
Biological Process GO:0015031 protein transport

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.