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Overview

Uniprot IDD3ZTA8
Protein NameRNA-binding protein 33
Gene NameRbm33
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1138 RGRLMPNKQNLRVVE

Function

RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation

Protein Sequence

10 MAAALGAGGG 20 AGAGDDDFDQ 30 FDKPGAERSW 40 RRRAADEDWD 50 SELEDDLLGE 60 DLLSGKKNQS 70 DLSDEELNDD 80 LLQSDNEDEE 90 NFSSQGVTIS 100 LNTTSGIVTS 110 FELSDNTNDQ 120 SGEQESEYEQ 130 GDDELAYHKP 140 EEQELYTQEY 150 PEEGQYEGHD 160 TELTEDQIEY 170 GDEPEEEQLY 180 SDEVLDIEIN 190 EPLDEFTDEE 200 YLQAYGGQQG 210 LQVREDCEAE 220 DDLDEITDSQ 230 VASETHEGGM 240 ETLELQKDIK 250 EESDEEDDDD 260 EESGRLRFKT 270 ERKEGTIIRL 280 SDVTRERRNI 290 PETLELSAEA 300 KAALLEFEER 310 ERQHKQGRYG 320 SRRGGRRGGS 330 LMCRGMGDQR 340 RDNSERGRMK 350 EHRPALLPTQ 360 PPVVAHSPRL 370 IPPPQQQPPP 380 PPPPPQQQPI 390 RSLFQQQQLQ 400 PLLPLQHPHH 410 PSPPQGVHMP 420 PQIETPRMML 430 TPPPVTPQQP 440 KNIHINPHFK 450 GTVVTPVQVP 460 LLPVPSQPRP 470 AVGPQRFPGP 480 PEFPQHTPGP 490 VPNSFNQPPR 500 LPLQDQWRAP 510 PPPQERDPFF 520 LGVSGEPRFP 530 SHLFLEQRSP 540 PPPPPPPTLL 550 NSSHPVPTQS 560 PLPFTQPGPA 570 FNQQGQQPVF 580 PRERPVRPAL 590 QPPGPVGILH 600 FSQPGSATAR 610 PFIPPRQPFL 620 PSPGQPFLPT 630 HAQPNLQGPL 640 HPPLPPPHQP 650 QPQPQQPQQQ 660 PQHHQHQPPL 670 QPPLQPPHQP 680 PPQHQPPPQH 690 QPQQHQHHHH 700 LSAPPPPLMP 710 MSQPQFRPHV 720 QTAQPQSNSS 730 RMQCTPRQGL 740 RHNTASQNIS 750 KRPMQQMQPT 760 APRNSNLREL 770 PIAPSHVLEM 780 SGNRCSSTPA 790 AQVKSIANTS 800 PPCRAVVASR 810 SSQGKTDAKA 820 KPLSPGAQPK 830 EEAKAEAEFP 840 DEDEETRLYR 850 LKIEEQKRLR 860 EEILKQKELR 870 RQQQAGARKK 880 ELLERLAQQQ 890 QQQQQQQQQQ 900 QQQIYGSQTP 910 MEQEELAATP 920 SPTNGNPLLP 930 FPGTQCRQNV 940 KTRLLVKNQD 950 VTAANVQPKA 960 VNFVPPGANM 970 QHQGQHLRPL 980 KHLRQLPHKV 990 LHVKPMDMEE 1000 TPHSPQAARV 1010 TSLQGRPQDT 1020 KPGVKRTVMH 1030 RANSGGGGDG 1040 PHVSSKVRVI 1050 KLSGGQGGES 1060 DGFSHTEGQP 1070 QRLPQPPDMR 1080 QQPTRKVTLT 1090 KGVPQQPQHL 1100 PVGPHMYPAI 1110 PPGIKSIQGI 1120 HPAKKAIMHG 1130 RGRGVAGPMG 1140 RGRLMPNKQN 1150 LRVVECKPQP 1160 CVVSVEGLSS 1170 STTDVQLKSL 1180 LMSVGPIQSL 1190 QMLPQQRKAI 1200 AKFKEPAHAL 1210 AFQQKFHRHM 1220 IDLSHINVAL IVE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:1990247 N6-methyladenosine-containing RNA reader activity
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0051028 mRNA transport
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0006405 RNA export from nucleus

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.