Search Results
Overview
| Uniprot ID | D3ZTX9 |
|---|---|
| Protein Name | Large ribosomal subunit protein uL23 |
| Gene Name | Rpl23a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | KEAPAPPKAEAKAKA |
| 7 | *MAPKAKKEAPAPPK |
Function
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination
Protein Sequence
10
MAPKAKKEAP
20
APPKAEAKAK
30
ALKAKKAVLK
40
GIHSHKKKKI
50
RTSPTFRRPE
60
TLRLQRQPKY
70
PRKSAPRRNK
80
LDRYAIIKFP
90
LTTESAMKKI
100
EDNHTLVFTV
110
DVKANKHQVK
120
QAVKKLYDID
130
VAKVNTLIRP
140
DGEKKAYVHS
150
APDYEALDVA
NKIGIIG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0022625 | cytosolic large ribosomal subunit |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0019843 | rRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0006412 | translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.