Overview
| Uniprot ID | D3ZU52 |
|---|
| Protein Name | - |
|---|
| Gene Name | Cops7b |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 315 |
TKKMSKVKGLVSSRH |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MQQWEASGGT
20
APVTGRRRQK
30
SAGRRSDHGS
40
LTTCRQALGG
50
RDIGEENRVG
60
GDRSQDQRMA
70
GEQKPSSNLL
80
EQFILLAKGT
90
SGSALTTLIS
100
QVLEAPGVYV
110
FGELLELANV
120
QELAEGANAA
130
YLQLLNLFAY
140
GTYPDYIANK
150
ESLPELSAAQ
160
QNKLKHLTIV
170
SLASRMKCIP
180
YSVLLKDLEM
190
RNLRELEDLI
200
IEAVYTDIIQ
210
GKLDQRNQLL
220
EVDFCIGRDI
230
QKKDINNIVK
240
TLHEWCDGCE
250
AVLLGIEQQV
260
LRANQYKENH
270
HRTQQQVEAE
280
VSNIKKTLKA
290
TASSSAQEME
300
QQLAERECPP
310
HTEQRQPTKK
320
MSKVKGLVSS
RH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0010387 |
COP9 signalosome assembly |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.