Overview
| Uniprot ID | D3ZU54 |
|---|
| Protein Name | Density-regulated protein |
|---|
| Gene Name | Denr |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 18 |
ADTKNSAKLDADYPL |
Function
Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent
Protein Sequence
10
MATDISESSG
20
ADTKNSAKLD
30
ADYPLRVLYC
40
GVCSLPTEYC
50
EYMPDVAKCR
60
QWLEKNFPNE
70
FAKLTVENSP
80
KQETGISEGQ
90
GPVGEEEEKK
100
KQKRGGRGQI
110
KQKKKTVPQK
120
VTIAKIPRAK
130
KKYVTRVCGL
140
ATFEIDLKEA
150
QRFFAQKFSC
160
GASVTGEDEI
170
IIQGDFTDDI
180
IDVIQEKWPE
190
VDDDSIEDLG
EVKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Biological Process |
GO:0001731 |
formation of translation preinitiation complex |
| Biological Process |
GO:0075522 |
IRES-dependent viral translational initiation |
| Biological Process |
GO:0032790 |
ribosome disassembly |
| Biological Process |
GO:0002188 |
translation reinitiation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.