Search Results
Overview
| Uniprot ID | D3ZUL8 |
|---|---|
| Protein Name | Zinc finger CCHC domain-containing protein 8 |
| Gene Name | Zcchc8 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 681 | LRIRNLLKNSPRNQQ |
Function
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function
Protein Sequence
10
MAAGVDFGDL
20
ELFEAFDPQE
30
ESTPKPVHTR
40
FKDDEEEDDD
50
DDENGVGDAE
60
LQEQLRRCEE
70
TIEQLRAENQ
80
ELKRKLNILT
90
RPSGILVSNT
100
KIDGPLLQIL
110
FMNNAISKQY
120
HQEIEEFVSN
130
LVKRFEEQQK
140
NDVEKTSFSL
150
LPQPSSVMLE
160
EDRKVEESCA
170
IKNNKEAFSV
180
VGSVLYFTNF
190
CLDKLGQPLL
200
NENPQLTEGW
210
EIPKYQQVFS
220
HIVSLEGQEM
230
QVKAKRPKPH
240
CFNCGSEEHQ
250
MKECPMPRNA
260
ARISEKRKEY
270
MDACGEANSQ
280
SFQQRYHAEE
290
VEERFGRFKP
300
GVISEELQDA
310
LGVTDKSLPP
320
FIYRMRQLGY
330
PPGWLKEAEL
340
ETSGLALYDG
350
NDDADGETET
360
GEIQNKNVTY
370
DLSKLVNYPG
380
FNISTPRGIP
390
DEWRMFGSIP
400
MQACQQKDVF
410
ASYLNSNIQS
420
PSVKSSSKRS
430
SSQSSPNSPK
440
KQRREGSAAA
450
SPADMELDSD
460
IEIPPGSQSS
470
KAFQFQPPLP
480
PGTPPPLPQG
490
TPPPLFTPPL
500
PKGTPPLTPS
510
DSPQPRPTAS
520
GVDEDALTLE
530
ELEEQQRQIW
540
AALQQAEGAN
550
SDSDVPMDTP
560
LTGNSVASSP
570
CPNEFDLRVP
580
EGRALEKPVL
590
AEPDTASPEP
600
SCSPAAEAAV
610
LSQKEEGVSA
620
EGDPGDGLLD
630
NGGVLNISNG
640
GNHLDTRPPT
650
ASKTHSPVPD
660
MSKFAHGITP
670
FEFENMAEST
680
GMYLRIRNLL
690
KNSPRNQQKN
KKTSE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0062141 | nuclear exosome targeting complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031499 | TRAMP complex |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0180034 | co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway |
| Biological Process | GO:0031124 | mRNA 3'-end processing |
| Biological Process | GO:0006396 | RNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.