Search Results
Overview
| Uniprot ID | D3ZUV3 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 2A |
| Gene Name | Eif2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | AVYVPGSKGAPSFVR |
Function
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner
Protein Sequence
10
MGFSFRDKMA
20
PSTPLLTVRG
30
SEGLYMVNGP
40
PHFTESTVLP
50
REPGKNCKVY
60
TFSKDGTLFA
70
WSNGEKVNII
80
NVANKGLLHS
90
FDLPKAVCLE
100
FSPNNTVLAT
110
WQPYTTSKDG
120
TAGTPNLQLY
130
DVKTGTCLKS
140
FIQKKMQNWC
150
PSWSDDEIIC
160
ARNVNNEVHF
170
FENNNFNTIA
180
NKLHLQKVND
190
FNLSPGTQPF
200
KVAVYVPGSK
210
GAPSFVRLYQ
220
YPNFAGPQAA
230
LANKSFFKAD
240
KVTMLWNKKA
250
TAVLVIASTD
260
VDKTGASYYG
270
EQTLHYIATN
280
GESAVVQLPK
290
NGPIYDVAWN
300
PSSTEFCAVY
310
GFMPAKATVF
320
NLKCDPVFDF
330
GTGPRNAAFY
340
SPHGHILVLA
350
GFGNLRGQME
360
VWDVKNYKLI
370
SKPVASDSTY
380
FAWCPDGEHI
390
LTATCAPRLR
400
VNNGYKIWHY
410
TGSLLYKYDV
420
PSNGELWQVS
430
WQPFLDGIFP
440
AKTITYQAVP
450
SEVPSEEPKV
460
ATAYRPPALR
470
NKPVTSSKLH
480
EEEPPQNMKP
490
HPSSDKPLSK
500
TALKNQRKHE
510
AKKAAKQEAR
520
NDLAPTPVPQ
530
SAPRSTVTQS
540
ASGDPEVDKK
550
IKNLKKKLKA
560
IEQLKEQAAA
570
GKQLEKNQLE
580
KIQKETALLQ
ELEDLELGV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005850 | eukaryotic translation initiation factor 2 complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0006413 | translational initiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.